{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:53:22Z","timestamp":1790549602097,"version":"4.1.0"},"reference-count":50,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2003,5,28]]},"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>To assess the occurrence and nature of sleep-disordered breathing (SDB) in 26 adult, nonobese diabetics (18 with autonomic neuropathy (DAN+) (age 45 (41\u201350) yrs; body mass index (BMI) 24.1 (22\u201326) kg\u00b7m<jats:sup>\u22122<\/jats:sup>) and eight without autonomic neuropathy (DAN\u2212) (age 45 (35\u201355) yrs; BMI 24.8 (23\u201326) kg\u00b7m<jats:sup>\u22122<\/jats:sup>)) overnight full sleep studies and measurements of central and peripheral carbon dioxide (CO<jats:sub>2<\/jats:sub>) chemosensitivity were performed.<\/jats:p><jats:p>DAN+ were divided in two subgroups, according to the presence (DAN+PH+; n=10) or absence (DAN+PH\u2212; n=8) of postural hypotension. Ten normal subjects were studied as controls (age 42 (36\u201348) yrs; BMI 24.4 (23\u201325) kg\u00b7m<jats:sup>\u22122<\/jats:sup>).<\/jats:p><jats:p>In contrast to DAN\u2212 and controls, who did not show SDB, five DAN+ (four DAN+PH\u2212 and one DAN+PH+) had an apnoea\/hypopnoea index \u226510 and four DAN+ (two DAN+PH\u2212 and two DAN+PH+) had an apnoea index \u22655. All the events were obstructive, occurring mainly during rapid eye movement (REM) sleep. Ten DAN+ exhibited a mean lowest oxygen saturation &lt;90% during REM sleep. No periodic breathing or central sleep apnoeas were found in DAN+PH+, although they had an enhanced central chemoresponsiveness to CO<jats:sub>2<\/jats:sub>. Both DAN+ subgroups showed a marked reduction in peripheral CO<jats:sub>2<\/jats:sub>chemosensitivity.<\/jats:p><jats:p>In conclusion, adult nonobese diabetics with autonomic neuropathy, independent of the severity of their dysautonomy, have obstructive sleep apnoea\/hypopnoea with a frequency &gt;30%. A decrease in peripheral carbon dioxide chemosensitivity prevents adult nonobese diabetics with autonomic neuropathy and postural hypotension from experiencing posthyperventilatory central sleep apnoea, despite an increased hypercapnic central drive.<\/jats:p>","DOI":"10.1183\/09031936.03.00070402","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"654-660","source":"Crossref","is-referenced-by-count":70,"title":["Sleep-disordered breathing in nonobese diabetic subjects with autonomic neuropathy"],"prefix":"10.1183","volume":"22","author":[{"given":"P.","family":"Bottini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Dottorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cristina Cordoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Casucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tantucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"2024101810291650000_22.4.654.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91040-1"},{"key":"2024101810291650000_22.4.654.2","first-page":"935","volume":"i","year":"1978","journal-title":"Lancet"},{"key":"2024101810291650000_22.4.654.3","first-page":"304","volume":"2","year":"1980","journal-title":"Ann Intern Med"},{"key":"2024101810291650000_22.4.654.4","first-page":"14","volume":"i","year":"1990","journal-title":"Lancet"},{"key":"2024101810291650000_22.4.654.5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/sleep\/4.3.263","volume":"4","year":"1981","journal-title":"Sleep"},{"key":"2024101810291650000_22.4.654.6","doi-asserted-by":"publisher","DOI":"10.1177\/014107688107400306"},{"key":"2024101810291650000_22.4.654.7","doi-asserted-by":"publisher","DOI":"10.2337\/diab.33.11.1025"},{"key":"2024101810291650000_22.4.654.8","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01053-G"},{"key":"2024101810291650000_22.4.654.9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1183\/09031936.98.11010014","volume":"11","year":"1998","journal-title":"Eur Respir J"},{"key":"2024101810291650000_22.4.654.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.1.145"},{"key":"2024101810291650000_22.4.654.11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/jappl.2001.90.3.889","volume":"90","year":"2001","journal-title":"J Appl Physiol"},{"key":"2024101810291650000_22.4.654.12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1164\/ajrccm.150.2.8049836","volume":"150","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810291650000_22.4.654.13","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1164\/ajrccm.152.6.8520761","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810291650000_22.4.654.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411304"},{"key":"2024101810291650000_22.4.654.15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/bmj.285.6346.916","volume":"285","year":"1982","journal-title":"BMJ"},{"key":"2024101810291650000_22.4.654.16","first-page":"261","volume":"287","year":"1983","journal-title":"BMJ"},{"key":"2024101810291650000_22.4.654.17","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.7.1055"},{"key":"2024101810291650000_22.4.654.18","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"2024101810291650000_22.4.654.19","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(75)90059-6"},{"key":"2024101810291650000_22.4.654.20","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(73)90061-3"},{"key":"2024101810291650000_22.4.654.21","first-page":"20","volume":"16","year":"1967","journal-title":"Aust Ann Med"},{"key":"2024101810291650000_22.4.654.22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/sleep\/20.6.406","volume":"20","year":"1997","journal-title":"Sleep"},{"key":"2024101810291650000_22.4.654.23","unstructured":"Rechtschaffen A, Kale A, A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. 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