{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:17:29Z","timestamp":1789532249932,"version":"build-2803163510"},"reference-count":19,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2003,3,25]]},"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Patients with kyphoscoliosis and chronic respiratory insufficiency are treated either with home oxygen therapy or ventilation. Kyphoscoliotic patients demonstrate impaired ventilatory mechanics, consequently ventilation seems to be the treatment of choice. Yet, no randomised controlled trials (CRT) exist to prove it.<\/jats:p><jats:p>Most investigators find it difficult to ethically justify a CRT. Therefore, the current authors performed the following retrospective study: survival and pulmonary function were analysed in all consecutive kyphoscoliotic patients who started long-term oxygen therapy (LTO group; n=15, aged 62\u00b111\u2005yrs (mean\u00b1sd)) or LTO plus nocturnal nasal intermittent positive pressure ventilation (nNIPPV group; n=18, aged 61\u00b17\u2005yrs) in the Dept of Pulmonology (University Hospital Gasthuisberg, Leuven) between 1990\u20132002.<\/jats:p><jats:p>Prior to treatment partial pressure of oxygen (<jats:italic>P<\/jats:italic><jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>) was lower, partial pressure of carbon dioxide (<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>) tended to be higher and vital capacity (VC) tended to be lower in the nNIPPV group than in the LTO group (<jats:italic>P<\/jats:italic><jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>5.9\u00b11<jats:italic>versus<\/jats:italic>6.7\u00b10.9\u2005kPa (44\u00b18<jats:italic>versus<\/jats:italic>50\u00b17\u2005mmHg),<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>8\u00b11<jats:italic>versus<\/jats:italic>7.3\u00b10.9\u2005kPa (60\u00b18<jats:italic>versus<\/jats:italic>55\u00b17\u2005mmHg), VC 32\u00b112<jats:italic>versus<\/jats:italic>40\u00b116% predicted, or 645\u00b1244<jats:italic>versus<\/jats:italic>970\u00b1387 mL). In the nNIPPV group the 1\u2010yr survival was higher (100%<jats:italic>versus<\/jats:italic>66%). nNIPPV patients demonstrated an improvement in<jats:italic>P<\/jats:italic><jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>(breathing air) +54%,<jats:italic>P<\/jats:italic><jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>(breathing air) \u221221%, VC +47% and maximal static inspiratory mouth pressure +33%; these improvements were absent in the LTO group.<\/jats:p><jats:p>In conclusion, nocturnal nasal intermittent positive pressure ventilation, plus long-term oxygen therapy results in more favourable survival and changes in blood gases and respiratory function than long-term oxygen therapy alone.<\/jats:p>","DOI":"10.1183\/09031936.03.00076103","type":"journal-article","created":{"date-parts":[[2003,8,28]],"date-time":"2003-08-28T03:41:26Z","timestamp":1062042086000},"page":"525-528","source":"Crossref","is-referenced-by-count":81,"title":["Treatment of chronic respiratory failure in kyphoscoliosis: oxygen or ventilation?"],"prefix":"10.1183","volume":"22","author":[{"given":"B.","family":"Buyse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Meersseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Demedts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2024101810270428000_22.3.525.1","doi-asserted-by":"crossref","unstructured":"Bergofsky EH, Turino GM, Fishman AP. 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