{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:43Z","timestamp":1791245443452,"version":"4.1.0"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2003,6,27]]},"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>A randomised, double-blind, placebo-controlled study was conducted to evaluate the effects of theophylline and acetazolamide in the treatment of sleep-disordered breathing (SDB) after fast ascent to high altitude (3,454\u2005m).<\/jats:p><jats:p>The study was conducted at a high-altitude research laboratory and included 30 healthy male volunteers. Study medication was either oral slow release theophylline (2\u00d7250\u2005mg\u00b7day<jats:sup>\u22121<\/jats:sup>), oral acetazolamide (2\u00d7250\u2005mg\u00b7day<jats:sup>\u22121<\/jats:sup>) or a matched placebo tablet. Polysomnographic measurements were performed during two consecutive nights, and acute mountain sickness, pulse rate, oxyhaemoglobin saturation and arterial blood gases were assessed three times a day.<\/jats:p><jats:p>Without active medication, the apnoea\/hypopnoea index (AHI) was highly pathological (median 16.2\u00b7h<jats:sup>\u22121<\/jats:sup>, range 2\u201392). Both theophylline and acetazolamide normalised SDB (median AHI 2.5\u00b7h<jats:sup>\u22121<\/jats:sup>, range 0\u201311; 4.2\u00b7h<jats:sup>\u22121<\/jats:sup>, range 0\u201319, respectively) and reduced oxyhaemoglobin desaturations during sleep (median desaturation index placebo 41.5\u00b7h<jats:sup>\u22121<\/jats:sup>, range 6\u2013114; acetazolamide 6.5\u00b7h<jats:sup>\u22121<\/jats:sup>, range 3\u201328; theophylline 8.5\u00b7h<jats:sup>\u22121<\/jats:sup>, range 3\u201332). Compared with the high amount of central apnoeas or hypopnoeas, the number of obstructive events during sleep was very low in all groups (&lt;4\u00b7h<jats:sup>\u22121<\/jats:sup>). In contrast to theophylline, acetazolamide significantly improved basal oxyhaemoglobin saturation during sleep (86.2\u00b11.7%<jats:italic>versus<\/jats:italic>81.0\u00b13.0%).<\/jats:p><jats:p>The authors conclude that both oral slow release theophylline and acetazolamide are effective to normalise high-altitude sleep-disordered breathing.<\/jats:p>","DOI":"10.1183\/09031936.03.00113102","type":"journal-article","created":{"date-parts":[[2004,1,5]],"date-time":"2004-01-05T22:39:37Z","timestamp":1073342377000},"page":"47-52","source":"Crossref","is-referenced-by-count":95,"title":["Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude"],"prefix":"10.1183","volume":"23","author":[{"given":"R.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leitl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2024101810395332000_23.1.47.1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/ajrccm\/145.4_Pt_1.817","volume":"145","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2024101810395332000_23.1.47.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020408"},{"key":"2024101810395332000_23.1.47.3","doi-asserted-by":"publisher","DOI":"10.1089\/15270290050502408"},{"key":"2024101810395332000_23.1.47.4","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00057-7"},{"key":"2024101810395332000_23.1.47.5","unstructured":"Weil JV, Kryger MH, Scoggin CH. 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