{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:48:38Z","timestamp":1770432518997,"version":"3.49.0"},"reference-count":52,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2002,10,1]]},"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>This study has investigated the role of average maximum inspiratory effort in excessive daytime sleepiness in patients with obstructive sleep apnoea syndrome (OSAS) and upper airway resistance syndrome (UARS).<\/jats:p><jats:p>Fifteen patients diagnosed with UARS and 32 patients with OSAS, with &gt;5.5\u2005h total sleep time (TST) during 8\u2005h of nocturnal polygraphic recordings, were included in the study. Demographical data, polysomnographical data and data about daytime sleepiness, including Epworth sleepiness scale (ESS) and multiple sleep latency test (MSLT), were evaluated. In order to compute the average maximum inspiratory effort from oesophageal pressure (<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>) measurements, maximum<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>was obtained from 20 representative obstructive respiratory events (obstructive apnoeas, hypopnoeas or flow limitations) for each sleep stage in both supine and side positions. From<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>measurements during sleep, the increase in<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>(\u0394<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>) during respiratory events was also calculated.<\/jats:p><jats:p>The average maximum<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>, \u0394<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>, respiratory disturbance index (RDI) and arousal index were significantly correlated with ESS in OSAS patients. In patients with UARS, the only significant correlation was obtained between average maximum<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>and ESS. The MSLT score did not show any significant correlation with arousal index, number of stage variations, RDI, average<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>, \u0394<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>, minimum oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>) and percentage of TST with an<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>&lt;90% in both UARS and OSAS patients. The results of multiple regression analysis showed that average maximum<jats:italic>P<\/jats:italic><jats:sub>oes<\/jats:sub>correlates best with the variance in ESS for OSAS patients.<\/jats:p><jats:p>In conclusion, the data from this study indicate the possible important role of average inspiratory effort in determining subjective sleepiness in both obstructive sleep apnoea syndrome and upper airway resistance syndrome patients.<\/jats:p>","DOI":"10.1183\/09031936.03.00298903","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"688-694","source":"Crossref","is-referenced-by-count":27,"title":["The role of mean inspiratory effort on daytime sleepiness"],"prefix":"10.1183","volume":"21","author":[{"given":"Z.","family":"Pelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"G\u00f6z\u00fckirmizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kaynak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"2024101810105840000_21.4.688.1","first-page":"209","volume":"17","year":"1985","journal-title":"Ann Clin Res"},{"key":"2024101810105840000_21.4.688.2","unstructured":"Guilleminault C.. 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