{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:34:08Z","timestamp":1781242448838,"version":"3.54.1"},"reference-count":14,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,3,30]]},"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>Nasal nitric oxide levels are low in patients with primary ciliary dyskinesia, but it is not known whether this defect is already present in the first months of life.<\/jats:p><jats:p>The current authors measured nasal nitric oxide in two infants with<jats:italic>situs inversus<\/jats:italic>and primary ciliary dyskinesia, diagnosed by electron microscopy at 4 and 6 months of age, and in five healthy control infants.<\/jats:p><jats:p>Nasal nitric oxide values in the primary ciliary dyskinesia infants (85 and 115 parts per billion (ppb)) were markedly lower than in the healthy controls (mean: 295\u2005ppb, range: 225\u2013379\u2005ppb).<\/jats:p><jats:p>This is the first report to show that nasal nitric oxide values are already low in early life in primary ciliary dyskinesia children, supporting the hypothesis that a reduced production of nasal nitric oxide is an intrinsic feature of this disease. The current authors suggest that the nasal nitric oxide test may be a useful, noninvasive method for screening young children for primary ciliary dyskinesia in clinical practice.<\/jats:p>","DOI":"10.1183\/09031936.04.00000504","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T07:42:55Z","timestamp":1099208575000},"page":"881-883","source":"Crossref","is-referenced-by-count":22,"title":["Nasal nitric oxide is low early in life: case study of two infants with primary ciliary dyskinesia: Fig. 1.\u2014"],"prefix":"10.1183","volume":"24","author":[{"given":"E.","family":"Baraldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Cangiotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zanconato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zacchello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"2024101811030290000_24.5.881.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12040982"},{"key":"2024101811030290000_24.5.881.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07081501"},{"key":"2024101811030290000_24.5.881.3","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1183\/09031936.99.13614069","volume":"13","year":"1999","journal-title":"Eur Respir J"},{"key":"2024101811030290000_24.5.881.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13111499"},{"key":"2024101811030290000_24.5.881.5","first-page":"L911","volume":"268","year":"1995","journal-title":"Am J Physiol"},{"key":"2024101811030290000_24.5.881.6","doi-asserted-by":"publisher","DOI":"10.1038\/nm0495-370"},{"key":"2024101811030290000_24.5.881.7","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.586"},{"key":"2024101811030290000_24.5.881.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.0905-6157.2001.00000.x"},{"key":"2024101811030290000_24.5.881.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00293102"},{"key":"2024101811030290000_24.5.881.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00305503"},{"key":"2024101811030290000_24.5.881.11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.5.9154876"},{"key":"2024101811030290000_24.5.881.12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1203\/00006450-199607000-00025","volume":"40","year":"1996","journal-title":"Pediatr Res"},{"key":"2024101811030290000_24.5.881.13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.5.363"},{"key":"2024101811030290000_24.5.881.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102376"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.04.00000504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:48:20Z","timestamp":1740376100000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.04.00000504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,11,1]]},"published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1183\/09031936.04.00000504"],"URL":"https:\/\/doi.org\/10.1183\/09031936.04.00000504","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}