{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:31:19Z","timestamp":1792668679838,"version":"4.5.0"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,7,30]]},"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>The chronology of diaphragm and vastus lateralis adaptation in chronic obstructive pulmonary disease (COPD) has not been studied. The hypothesis of this study was that muscle changes would occur earlier in the diaphragm than in the vastus lateralis in COPD, a finding that would suggest that local factors would be more important than systemic factors in determining the muscle phenotypic expression, at least in mild-to-moderate disease.<\/jats:p><jats:p>The adaptation of the vastus lateralis and diaphragm muscles was evaluated in patients with mild-to-moderate COPD and in subjects with normal pulmonary function.<\/jats:p><jats:p>In both groups, the oxidative potential and the number of lipofuscin inclusions were higher in the diaphragm than in the vastus lateralis. Compared to control, the diaphragm in COPD had a higher oxidative capacity and a higher proportion of type I fibres, with a reciprocal decrease in type IIA fibres, while there was no difference in diaphragmatic cross sectional areas, capillarisation and lipofuscin inclusions. No significant differences were found in the vastus lateralis from both groups.<\/jats:p><jats:p>In conclusion, these data indicate that the diaphragm in controls and in chronic obstructive pulmonary disease has a higher oxidative potential than the vastus lateralis, and that muscle adaptation occurs earlier in the diaphragm than in the vastus lateralis in mild-to-moderate chronic obstructive pulmonary disease.<\/jats:p>","DOI":"10.1183\/09031936.04.00020204","type":"journal-article","created":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T18:48:06Z","timestamp":1101840486000},"page":"971-979","source":"Crossref","is-referenced-by-count":65,"title":["Adaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPD"],"prefix":"10.1183","volume":"24","author":[{"given":"M.","family":"Doucet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Debigar\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Joanisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gr\u00e9goire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deslauriers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Vaillancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Maltais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"2024101811054449000_24.6.971.1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/71.5.1033","volume":"71","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"2024101811054449000_24.6.971.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199810000-00001"},{"key":"2024101811054449000_24.6.971.3","first-page":"444","volume":"19","year":"2002","journal-title":"Rev Mal Respir"},{"key":"2024101811054449000_24.6.971.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00004607"},{"key":"2024101811054449000_24.6.971.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712183372503"},{"key":"2024101811054449000_24.6.971.6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00116.2001"},{"key":"2024101811054449000_24.6.971.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-519OC"},{"key":"2024101811054449000_24.6.971.8","first-page":"E567","volume":"257","year":"1989","journal-title":"Am J Physiol"},{"key":"2024101811054449000_24.6.971.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00022204"},{"key":"2024101811054449000_24.6.971.10","first-page":"S77","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101811054449000_24.6.971.11","first-page":"587","volume":"113","year":"1976","journal-title":"Am Rev Respir Dis"},{"key":"2024101811054449000_24.6.971.12","first-page":"454","volume":"79","year":"1959","journal-title":"Am Rev Tuberc"},{"key":"2024101811054449000_24.6.971.13","unstructured":"Cotes JE, Hall AM, The transfer factors for the lung; normal values in adults. In: Arcangeli P, ed. Normal Values for Respiratory Function in Man. Torino, Panminerva Medica, 1970; pp.\u2005327\u2013343."},{"key":"2024101811054449000_24.6.971.14","unstructured":"Heymsfield SB, Williams PJ, Nutritional assessment by clinical and biochemical methods. In: Shils ME, Olson JA, eds. Modern Nutrition in Health and Disease. Philadelphia, Lea & Febiger, 1994; pp.\u2005812\u2013841."},{"key":"2024101811054449000_24.6.971.15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365516209075148","volume":"14","year":"1962","journal-title":"Scand J Clin"},{"key":"2024101811054449000_24.6.971.16","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542131"},{"key":"2024101811054449000_24.6.971.17","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10039"},{"key":"2024101811054449000_24.6.971.18","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880030308"},{"key":"2024101811054449000_24.6.971.19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1748-1716.1984.tb07543.x","volume":"122","year":"1984","journal-title":"Acta Physiol Scand"},{"key":"2024101811054449000_24.6.971.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266407"},{"key":"2024101811054449000_24.6.971.21","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1152\/jappl.1989.66.5.2454","volume":"66","year":"1989","journal-title":"J Appl Physiol"},{"key":"2024101811054449000_24.6.971.22","first-page":"37A","volume":"10","year":"2003","journal-title":"Can Respir J"},{"key":"2024101811054449000_24.6.971.23","doi-asserted-by":"crossref","first-page":"L527","DOI":"10.1152\/ajplung.1998.274.4.L527","volume":"274","year":"1998","journal-title":"Am J Physiol Lung (Cell Mol Physiol)"},{"key":"2024101811054449000_24.6.971.24","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.10.848"},{"key":"2024101811054449000_24.6.971.25","first-page":"569","volume":"17","year":"2000","journal-title":"Rev Mal Respir"},{"key":"2024101811054449000_24.6.971.26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1183\/09031936.93.04050587","volume":"4","year":"1991","journal-title":"Eur Respir J"},{"key":"2024101811054449000_24.6.971.27","first-page":"901","volume":"18","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024101811054449000_24.6.971.28","first-page":"574","volume":"17","year":"2000","journal-title":"Rev Mal Respir"},{"key":"2024101811054449000_24.6.971.29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/00005768-199706000-00003","volume":"29","year":"1997","journal-title":"Med Sci Sports Exerc"},{"key":"2024101811054449000_24.6.971.30","first-page":"A298","volume":"153","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101811054449000_24.6.971.31","first-page":"351","volume":"21","year":"1985","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024101811054449000_24.6.971.32","doi-asserted-by":"crossref","first-page":"C666","DOI":"10.1152\/ajpcell.1996.271.2.C666","volume":"271","year":"1996","journal-title":"Am J Physiol Cell Physiol"},{"key":"2024101811054449000_24.6.971.33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0079-6123(08)64304-6","volume":"70","year":"1986","journal-title":"Prog Brain Res"},{"key":"2024101811054449000_24.6.971.34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1699-0463.1998.tb01346.x","volume":"106","year":"1998","journal-title":"APMIS"},{"key":"2024101811054449000_24.6.971.35","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90155-X"},{"key":"2024101811054449000_24.6.971.36","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/36.5.529"},{"key":"2024101811054449000_24.6.971.37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0891-5849(94)90142-2","volume":"16","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"2024101811054449000_24.6.971.38","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.8.704"},{"key":"2024101811054449000_24.6.971.39","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00005768-199907000-00011","volume":"31","year":"1999","journal-title":"Med Sci Sports Exerc"},{"key":"2024101811054449000_24.6.971.40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1028OC"},{"key":"2024101811054449000_24.6.971.41","doi-asserted-by":"publisher","DOI":"10.1063\/1.1381002"},{"key":"2024101811054449000_24.6.971.42","doi-asserted-by":"publisher","DOI":"10.1063\/1.365796"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.04.00020204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:48:32Z","timestamp":1740376112000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.04.00020204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,12,1]]},"published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1183\/09031936.04.00020204"],"URL":"https:\/\/doi.org\/10.1183\/09031936.04.00020204","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}