{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:47:55Z","timestamp":1762998475977,"version":"3.37.3"},"reference-count":12,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,8,16]]},"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Severe acute respiratory syndrome (SARS) is a highly infectious respiratory infection with a high mortality. The duration of infectivity is unknown. The RT-PCR positivity for SARS-associated coronavirus (SARS-CoV) was followed in 45 virologically confirmed SARS patients.<\/jats:p><jats:p>Serial RT-PCRs for SARS-CoV were performed in the nasopharyngeal aspirate, stool and urine of 45 SARS patients who survived until discharge. All patients had at least one site that was positive for SARS-CoV on presentation. Time to RT-PCR conversion was studied in all patients.<\/jats:p><jats:p>There were 15 males (33.3%) and 30 females (66.7%), with a mean\u00b1<jats:sc>sd<\/jats:sc>age of 40.7\u00b114.7 yrs. The median (range) time of RT-PCR conversion was 30 days (2\u201381). On discharge from the hospital, 18 (40%) remained RT-PCR positive in at least one site. For patients with positive RT-PCR on discharge, the median (range) time to RT-PCR conversion after discharge was 13 days (2\u201360).<\/jats:p><jats:p>A significant proportion of severe acute respiratory syndrome patients remained RT-PCR positive for severe acute respiratory syndrome-associated coronavirus for a substantial duration after discharge. The clinical significance is unknown and this finding merits further study. It is prudent to advise patients to adhere to strict personal hygiene on discharge until RT-PCR becomes negative.<\/jats:p>","DOI":"10.1183\/09031936.04.00057804","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T16:19:05Z","timestamp":1105114745000},"page":"12-14","source":"Crossref","is-referenced-by-count":29,"title":["Duration of RT-PCR positivity in severe acute respiratory syndrome"],"prefix":"10.1183","volume":"25","author":[{"given":"C. M.","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. S.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C. C.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W. N.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y. M.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Y.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2024101811061551000_25.1.12.1","unstructured":"World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. www.who.int\/csr\/sars\/country\/table2004_04_21\/en\/. Date last updated: April 21 2004; Date last accessed: October 22 2004."},{"key":"2024101811061551000_25.1.12.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086478"},{"key":"2024101811061551000_25.1.12.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086616"},{"key":"2024101811061551000_25.1.12.4","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1098\/rspb.2003.2481","volume":"270","year":"2003","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"2024101811061551000_25.1.12.5","unstructured":"World Health Organization. WHO hospital discharge and follow-up policy for patients who have been diagnosed with severe acute respiratory syndrome (SARS). www.who.int\/csr\/sars\/discharge\/en. Date last updated: March 28 2003; Date last accessed: October 22 2004."},{"key":"2024101811061551000_25.1.12.6","first-page":"330","volume":"115","year":"2003","journal-title":"Am J Med"},{"key":"2024101811061551000_25.1.12.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13265-5"},{"key":"2024101811061551000_25.1.12.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13412-5"},{"key":"2024101811061551000_25.1.12.9","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.012658"},{"key":"2024101811061551000_25.1.12.10","doi-asserted-by":"publisher","DOI":"10.1373\/49.6.953"},{"key":"2024101811061551000_25.1.12.11","first-page":"294","volume":"2","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"2024101811061551000_25.1.12.12","doi-asserted-by":"publisher","DOI":"10.1086\/382681"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.04.00057804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:49:03Z","timestamp":1740376143000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.04.00057804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1183\/09031936.04.00057804"],"URL":"https:\/\/doi.org\/10.1183\/09031936.04.00057804","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}