{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:42:17Z","timestamp":1782351737682,"version":"3.54.5"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2003,9,2]]},"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>In a curved tube, the amount of airflow appears to be influenced by the amount of curvature. The purpose of this study was to investigate changes in obstructive sleep apnoea (OSA) severity and awake velopharyngeal curvature in response to an anteriorly titrated mandibular position in 20 male OSA patients.<\/jats:p><jats:p>Baseline supine cephalometry was obtained before the initial insertion of a titratable oral appliance and follow-up supine cephalometry was undertaken after titration of the mandibular position with the appliance in place.<\/jats:p><jats:p>The mean apnoea\/hypopnea index (AHI) before treatment (31.6\u00b113.0\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>) was significantly reduced (9.8\u00b17.4\u2005events\u00b7h<jats:sup>\u22121<\/jats:sup>) after titration of the mandibular position in all 20 patients. There was a significant increase in the anteroposterior calibre and the radius of the curvature of the anterior wall of the velopharynx in 14 good responders who exhibited an AHI reduction to \u226415. Similar observations were not found in six poor responders.<\/jats:p><jats:p>To conclude, an anteriorly titrated mandibular position reduced obstructive sleep apnoea severity, enlarged the velopharynx and diminished the curvature of the anterior velopharyngeal wall in good responders. It is proposed that this change in the upper airway curvature associated with mandibular advancement may effect obstructive sleep apnoea severity through its effect on airflow dynamics.<\/jats:p>","DOI":"10.1183\/09031936.04.00094304","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T23:44:07Z","timestamp":1075938247000},"page":"263-268","source":"Crossref","is-referenced-by-count":72,"title":["Effects of mandibular advancement on airway curvature and obstructive sleep apnoea severity"],"prefix":"10.1183","volume":"23","author":[{"given":"S.","family":"Tsuiki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kawahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Fleetham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2004,2,1]]},"reference":[{"key":"2024101810414189000_23.2.263.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fl.15.010183.002333"},{"key":"2024101810414189000_23.2.263.2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7101(93)90052-8"},{"key":"2024101810414189000_23.2.263.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-999-0103-7"},{"key":"2024101810414189000_23.2.263.4","unstructured":"Lowe AA. Oral appliances for sleep breathing disorders In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 3rd EdnPhiladelphia, WB Saunders, 2000; pp.\u2005929\u2013939."},{"key":"2024101810414189000_23.2.263.5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/sleep\/24.5.554","volume":"24","year":"2001","journal-title":"Sleep"},{"key":"2024101810414189000_23.2.263.6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1136\/thx.54.11.972","volume":"54","year":"1999","journal-title":"Thorax"},{"key":"2024101810414189000_23.2.263.7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF03018915","volume":"47","year":"2000","journal-title":"Can J Anaesth"},{"key":"2024101810414189000_23.2.263.8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.16592800"},{"key":"2024101810414189000_23.2.263.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(97)70296-8"},{"key":"2024101810414189000_23.2.263.10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/sleep\/23.6.783","volume":"23","year":"2000","journal-title":"Sleep"},{"key":"2024101810414189000_23.2.263.11","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330440306"},{"key":"2024101810414189000_23.2.263.12","unstructured":"Hair JF, Anderson RE, Tatham RL, Black WC. Multivariate data analysis. 5th EdnNew Jersey, Prentice-Hall, 1998; pp.\u200533\u201386."},{"key":"2024101810414189000_23.2.263.13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9836"},{"key":"2024101810414189000_23.2.263.14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1164\/ajrccm\/147.3.624","volume":"147","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2024101810414189000_23.2.263.15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1164\/ajrccm.149.4.8143054","volume":"149","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810414189000_23.2.263.16","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903079"},{"key":"2024101810414189000_23.2.263.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1065"},{"key":"2024101810414189000_23.2.263.18","unstructured":"Kuna ST, Remmers JE. Anatomy and physiology of upper airway obstruction In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 3rd EdnPhiladelphia, WB Saunders, 2000; pp.\u2005840\u2013858."},{"key":"2024101810414189000_23.2.263.19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2004213"},{"key":"2024101810414189000_23.2.263.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.606"},{"key":"2024101810414189000_23.2.263.21","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1152\/jappl.1995.79.6.2132","volume":"79","year":"1995","journal-title":"J Appl Physiol"},{"key":"2024101810414189000_23.2.263.22","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-003-0043-6"},{"key":"2024101810414189000_23.2.263.23","first-page":"27","volume":"85","year":"1991","journal-title":"Respir Med"},{"key":"2024101810414189000_23.2.263.24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1115\/1.2798009","volume":"120","year":"1998","journal-title":"J Biomech Eng"},{"key":"2024101810414189000_23.2.263.25","doi-asserted-by":"crossref","unstructured":"Schwab R. Upper airway imaging. Sleep Disorders In: Strollo PJ Jr, Sanders MH, editors. Clinics in Chest Medicine. Volume 19, number 1Philadelphia, WB Saunders, 1998; pp.\u200533\u201354.","DOI":"10.1016\/S0272-5231(05)70430-5"},{"key":"2024101810414189000_23.2.263.26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/sleep\/26.4.440","volume":"26","year":"2003","journal-title":"Sleep"},{"key":"2024101810414189000_23.2.263.27","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630569"},{"key":"2024101810414189000_23.2.263.28","unstructured":"Lowe AA, Fleetham JA. Two- and three-dimensional analyses of tongue, airway, and soft palate size In: Norton ML, Brown ACD, editors. Atlas of the Difficult AirwaySt Louis, Mosby, 1991; pp.\u200574\u201382."},{"key":"2024101810414189000_23.2.263.29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/thx.52.4.362","volume":"52","year":"1997","journal-title":"Thorax"},{"key":"2024101810414189000_23.2.263.30","first-page":"624","volume":"99","year":"1969","journal-title":"Am Rev Respir Dis"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.04.00094304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:19:45Z","timestamp":1740377985000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.04.00094304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,2,1]]},"published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1183\/09031936.04.00094304"],"URL":"https:\/\/doi.org\/10.1183\/09031936.04.00094304","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}