{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:19:56Z","timestamp":1787019596546,"version":"build-2736575974"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,3,9]]},"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>\n                    Aspirin-induced asthma (AIA) is associated with increased production of cysteinyl leukotrienes (CysLT). Although leukotriene CysLT\n                    <jats:sub>1<\/jats:sub>\n                    -receptor antagonists improve lower airway outcomes in AIA, their effects and dose-response in the upper airway is less well documented.\n                  <\/jats:p>\n                  <jats:p>The present study evaluated the dose-response for montelukast (ML) against nasal lysine-aspirin challenge in patients with AIA.<\/jats:p>\n                  <jats:p>\n                    A total of 12 patients with a clear-cut history of AIA were randomised in double-blind cross-over fashion to receive single doses of ML 10\u2005mg, ML 40\u2005mg, or placebo (PL), with nasal lysine-aspirin challenge performed 12\u2005h after dosing. Measurements of peak nasal inspiratory flow (PNIF), nasal blockage visual analogue scale (VAS) and forced expiratory volume in one second (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ) were made over 120\u2005min after nasal lysine-aspirin challenge.\n                  <\/jats:p>\n                  <jats:p>\n                    Prechallenge values for mean\u00b1sem PNIF (L\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) were not significantly different comparing all groups: ML 10\u2005mg (132\u00b110), ML 40\u2005mg (125\u00b112) and PL (132\u00b111). There was no significant difference comparing the maximum % PNIF fall from baseline between screening (46\u00b16) and PL (45\u00b16). The maximum % PNIF fall from baseline was significantly greater with PL (45\u00b16) compared to either ML 10\u2005mg (34\u00b16) or ML 40\u2005mg (32\u00b15). There was also a significantly greater mean % PNIF response over 120\u2005min after lysine-aspirin challenge for PL (26\u00b17) compared to either ML 10\u2005mg (14\u00b16) or ML 40\u2005mg (17\u00b16). There were no significant differences for the maximum or mean % PNIF fall from baseline comparing ML 10\u2005mg and ML 40\u2005mg. A significant increase in nasal blockage VAS score was observed between baseline and 60\u2005min or 120\u2005min with PL but not with ML 10\u2005mg or ML 40\u2005mg. There were no significant differences for either the maximum or mean % FEV\n                    <jats:sub>1<\/jats:sub>\n                    over 120\u2005min as change from baseline comparing all groups.\n                  <\/jats:p>\n                  <jats:p>A single 10\u2005mg dose of montelukast partially protected against the local effects of nasal lysine-aspirin challenge, with no further benefit at 40\u2005mg. Nasal lysine-aspirin challenge appeared to be a reproducible and safe method in assessing patients with aspirin-induced asthma.<\/jats:p>","DOI":"10.1183\/09031936.04.00100303","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T20:08:45Z","timestamp":1090958925000},"page":"226-230","source":"Crossref","is-referenced-by-count":33,"title":["Montelukast protects against nasal lysine-aspirin challenge in patients with aspirin-induced asthma"],"prefix":"10.1183","volume":"24","author":[{"given":"D.K.C.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Haggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2004,8,1]]},"reference":[{"key":"2024101810543305000_24.2.226.1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1487"},{"key":"2024101810543305000_24.2.226.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542168"},{"key":"2024101810543305000_24.2.226.3","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124466"},{"key":"2024101810543305000_24.2.226.4","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1025","volume":"143","year":"1991","journal-title":"Am 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