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Difficulties arising with tuberculin skin-test surveys include logistical problems in sampling a representative portion of the population. Therefore, a compromise assesses the prevalence of infection among school children as an indicator of transmission in the community at large. The utilisation of tuberculin surveys is further compounded by the unpredictable specificity of the tuberculin skin test and, thus, the predictive value of a positive test result. Statistical approaches using mixture analysis may overcome this problem to some extent, but the experience is limited. Cytokine-derived assays, such as the interferon-\u03b3 release assays, are promising in providing higher specificity, but they require venepuncture.<\/jats:p>","DOI":"10.1183\/09031936.04.00103804","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T16:19:05Z","timestamp":1105114745000},"page":"181-185","source":"Crossref","is-referenced-by-count":50,"title":["Annual risk of infection with<i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1183","volume":"25","author":[{"given":"H.","family":"Rieder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2024101811065050000_25.1.181.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01710048"},{"key":"2024101811065050000_25.1.181.2","doi-asserted-by":"publisher","DOI":"10.2307\/2278457"},{"key":"2024101811065050000_25.1.181.3","first-page":"319","volume":"17","year":"1957","journal-title":"Bull World Health Organ"},{"key":"2024101811065050000_25.1.181.4","unstructured":"Cauthen GM, Pio A, ten Dam HG. 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