{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:37:46Z","timestamp":1770817066814,"version":"3.50.1"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,1,11]]},"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>High-altitude pulmonary oedema (HAPE) occurs in predisposed individuals at altitudes &gt;2,500\u2005m. Defective alveolar fluid clearance secondary to a constitutive impairment of the respiratory transepithelial sodium transport contributes to its pathogenesis. Hypoxia impairs the transepithelial sodium transport in alveolar epithelial type II cells<jats:italic>in vitro<\/jats:italic>. If this impairment is also present<jats:italic>in vivo<\/jats:italic>, high-altitude exposure could aggravate the constitutive defect in sodium transport in HAPE-prone subjects, and thereby further facilitate pulmonary oedema.<\/jats:p><jats:p>Therefore, the aim of the current study was to measure the nasal potential difference (PD) in 21 HAPE-prone and 29 HAPE-resistant subjects at low altitude and 30\u2005h after arrival at high altitude (4,559\u2005m).<\/jats:p><jats:p>High-altitude exposure significantly decreased the mean\u00b1sd nasal PD in HAPE-prone (18.0\u00b16.2<jats:italic>versus<\/jats:italic>12.5\u00b16.8\u2005mV) but not in HAPE-resistant subjects (25.6\u00b19.4<jats:italic>versus<\/jats:italic>22.9\u00b19.2\u2005mV). This altitude-induced decrease was not associated with an altered amiloride-sensitive fraction, but was associated with a significantly lower amiloride-insensitive fraction of the nasal PD.<\/jats:p><jats:p>These findings provide evidence<jats:italic>in vivo<\/jats:italic>that an environmental factor may impair respiratory transepithelial sodium transport in humans. They are consistent with the concept that in high-altitude pulmonary oedema-susceptible subjects, the combination of a constitutive and an acquired defect in this transport mechanism facilitates the development of pulmonary oedema during high-altitude exposure.<\/jats:p>","DOI":"10.1183\/09031936.04.00115304","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"916-920","source":"Crossref","is-referenced-by-count":57,"title":["High altitude impairs nasal transepithelial sodium transport in HAPE-prone 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