{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:30:20Z","timestamp":1790335820426,"version":"4.1.0"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,2,11]]},"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Endobronchial ultrasound (EBUS) allows identification of airway wall structures and could potentially be utilised for<jats:italic>in vivo<\/jats:italic>studies of airway thickening in asthma. The present study investigated whether inflation of the fluid-filled balloon sheath over the transducer (necessary to provide sonic coupling with the airway wall) influenced<jats:italic>in vitro<\/jats:italic>measurements.<jats:italic>In vivo<\/jats:italic>comparability of EBUS with high resolution computed tomography scanning (HRCT), an established method for measuring wall thickness, was determined in control subjects.<\/jats:p><jats:p>The airway diameter and wall thickness were studied using EBUS in 24 cartilaginous airways obtained from four sheep, before and after balloon sheath inflation during immersion in saline. To assess EBUS<jats:italic>versus<\/jats:italic>HRCT comparability of airway measures<jats:italic>in vivo<\/jats:italic>, 12 control subjects underwent imaging of the posterior basal bronchus of the right lower lobe by both techniques. Intra- and interobserver agreement were also assessed.<\/jats:p><jats:p>Results with and without the balloon sheath gave comparable measures of airway internal diameter and wall thickness<jats:italic>in vitro<\/jats:italic>. Statistical analysis showed agreement between EBUS and HRCT, and intra- and interobserver variability<jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>The current study concludes that endobronchial ultrasound, which does not present a radiation risk, could be utilised in the<jats:italic>in vivo<\/jats:italic>study of cartilaginous airway wall remodelling in respiratory diseases, such as asthma.<\/jats:p>","DOI":"10.1183\/09031936.04.00119904","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:25:02Z","timestamp":1221845102000},"page":"813-817","source":"Crossref","is-referenced-by-count":53,"title":["Endobronchial ultrasound to assess airway wall thickening: validation<i>in vitro<\/i>and<i>in vivo<\/i>"],"prefix":"10.1183","volume":"23","author":[{"given":"T.J.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Wakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Peebles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Howarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"2024101810495969000_23.6.813.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.7.565"},{"key":"2024101810495969000_23.6.813.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00349-X"},{"key":"2024101810495969000_23.6.813.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.5.1403"},{"key":"2024101810495969000_23.6.813.4","doi-asserted-by":"publisher","DOI":"10.1159\/000070066"},{"key":"2024101810495969000_23.6.813.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(00)00168-X"},{"key":"2024101810495969000_23.6.813.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.6.1887"},{"key":"2024101810495969000_23.6.813.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.01642001"},{"key":"2024101810495969000_23.6.813.8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1148\/radiol.2242011424","volume":"224","year":"2002","journal-title":"Radiology"},{"key":"2024101810495969000_23.6.813.9","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/0016-5085(89)91623-5","volume":"96","year":"1989","journal-title":"Gastroenterology"},{"key":"2024101810495969000_23.6.813.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.6.1500"},{"key":"2024101810495969000_23.6.813.11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/ajrccm.152.3.7663797","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810495969000_23.6.813.12","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.4.248"},{"key":"2024101810495969000_23.6.813.13","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.3.247"},{"key":"2024101810495969000_23.6.813.14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9909044"},{"key":"2024101810495969000_23.6.813.15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.4_Pt_1.772"},{"key":"2024101810495969000_23.6.813.16","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1164\/ajrccm.154.5.8912780","volume":"154","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2024101810495969000_23.6.813.17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/jappl.1992.73.1.307","volume":"73","year":"1992","journal-title":"J Appl Physiol"},{"key":"2024101810495969000_23.6.813.18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00004424-198409000-00011","volume":"19","year":"1984","journal-title":"Invest Radiol"},{"key":"2024101810495969000_23.6.813.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"2024101810495969000_23.6.813.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9805064"},{"key":"2024101810495969000_23.6.813.21","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.3.242"},{"key":"2024101810495969000_23.6.813.22","unstructured":"Referral Guidelines for Imaging, Report 118. 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