{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T02:23:51Z","timestamp":1794450231850,"version":"4.9.1"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2005,5,28]]},"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>The prevalence of respiratory symptoms increases with age. Age has been found to be negatively associated with large airway clearance. The small airways region is considered important for development of airway disease.<\/jats:p><jats:p>Clearance after the first 24\u2005h was studied in 46 healthy subjects with a wide age distribution, (mean 42, range 19\u201381\u2005yrs). All subjects inhaled monodisperse 6 \u03bcm Teflon particles labelled with<jats:sup>111<\/jats:sup>In, with an extremely slow inhalation flow (0.05\u2005L\u00b7s<jats:sup>\u22121<\/jats:sup>). The particles were mainly deposited in the small conducting airways. Lung retention was measured at 0 and 24\u2005h, and at 7, 14 and 21 days after inhalation.<\/jats:p><jats:p>Significant relationships were found for the individual 24\u2005h \u201clarge\u201d airway clearance in per cent of initial lung deposition with age, forced expiratory volume in one second and forced vital capacity. Age was negatively associated with \u201csmall\u201d airway clearance after 24\u2005h as estimated at 2, 7, 14 and 21 days. Using stepwise linear regression only age remained significantly associated to clearance.<\/jats:p><jats:p>In conclusion, small airway clearance over 21 days was found to decrease with age. 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