{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:02:34Z","timestamp":1790942554631,"version":"4.1.0"},"reference-count":16,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2005,8,7]]},"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>The present study assessed the usefulness of key items obtained from a clinical \u201copen\u201d questionnaire prospectively administered to 212 subjects, referred to four tertiary-care hospitals for predicting the diagnosis of occupational asthma (OA). Of these subjects, 72 (34%) were diagnosed as OA (53% with OA due to high-molecular-weight agents) according to results of specific inhalation challenges, and 90 (42%) as non-OA.<\/jats:p>\n                  <jats:p>Wheezing at work occurred in 88% of subjects with OA and was the most specific symptom (85%). Nasal and eye symptoms were commonly associated symptoms. Wheezing, nasal and ocular itching at work were positively, and loss of voice negatively associated with the presence of OA in the case of high-, but not low molecular-weight agents.<\/jats:p>\n                  <jats:p>A prediction model based on responses to nasal itching, daily symptoms over the week at work, nasal secretions, absence of loss of voice, wheezing, and sputum, correctly predicted 156 out of 212 (74%) subjects according to the presence or absence of OA by final diagnosis.<\/jats:p>\n                  <jats:p>\n                    In conclusion, key items,\n                    <jats:italic>i.e.<\/jats:italic>\n                    wheezing, nasal and ocular itching and loss of voice, are satisfactorily associated with the presence of occupational asthma in subjects exposed to high-molecular-weight agents. Therefore, these should be addressed with high priority by physicians. However, no questionnaire-derived item is helpful in subjects exposed to low-molecular-weight agents.\n                  <\/jats:p>","DOI":"10.1183\/09031936.05.00024705","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T14:52:54Z","timestamp":1133362374000},"page":"1056-1063","source":"Crossref","is-referenced-by-count":97,"title":["What are the questionnaire items most useful in identifying subjects with occupational asthma?"],"prefix":"10.1183","volume":"26","author":[{"given":"O.","family":"Vandenplas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ghezzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Moscato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Perfetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lemi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labrecque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L'Archev\u00eaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L.","family":"Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2024101811313308000_26.6.1056.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507133330207"},{"key":"2024101811313308000_26.6.1056.2","unstructured":"Bernstein DI. Clinical assessment and management of occupational asthma. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace. 2nd Edn. New York, Marcel Dekker Inc., 1999; pp.\u2005145\u2013157"},{"key":"2024101811313308000_26.6.1056.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071513"},{"key":"2024101811313308000_26.6.1056.4","unstructured":"Christiani DC, Malo JL. Upper airways involvement. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace. 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Occupational challenge tests. In: Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI, eds. Asthma in the Workplace. 2nd Edn. New York, Marcel Dekker Inc., 1999; pp.\u2005211\u2013233"},{"key":"2024101811313308000_26.6.1056.13","unstructured":"Breiman L, Friedman JH, Olshen RA, Stone CJ. Classification and regression trees. Wadsworth and Brooks, Monterey, CA, USA, 1984"},{"key":"2024101811313308000_26.6.1056.14","unstructured":"Computing R development Core Team. R Foundation for Statistical. R: A language and environment for statistical computing. Vienna, Austria 2004. http:\/\/www.R-project.org"},{"key":"2024101811313308000_26.6.1056.15","unstructured":"National Institutes of Health National Heart, Lung and Blood Institute. Global initiative for asthma (GINA). Global strategy for asthma management and prevention. NHLBI\/SHO workshop report. 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