{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:18:15Z","timestamp":1770337095727,"version":"3.49.0"},"reference-count":51,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,12,7]]},"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>As asthma is the most common chronic disease in childhood, much attention is directed towards primary prevention. Here, the clinical effectiveness of a multifaceted educational prevention was studied.<\/jats:p><jats:p>A total of 476 high-risk children were recruited during the prenatal period by general practitioners and randomised to either: 1) a control group, receiving usual care; or 2) an intervention group in which families received instruction from nurses on how to reduce exposure of newborns to mite, pet and food allergens, and passive smoking.<\/jats:p><jats:p>A total of 443 infants were followed-up for 2\u2005yrs. At 2\u2005yrs of age, the intervention group (n\u200a=\u200a222) had less asthma-like symptoms, including wheezing, shortness of breath and night-time cough, than the control group (n\u200a=\u200a221). No significant differences in total and specific immunoglobulin E were found between the groups. During the first 2\u2005yrs of life, the incidence of asthma-like symptoms was similar in both groups; however, subanalysis revealed a significant reduction in the female, but not in the male, intervention group.<\/jats:p><jats:p>In conclusion, the intervention used in this study was not effective in reducing asthma-like symptoms in high-risk children during the first 2\u2005yrs of life, although it was modestly effective at 2\u2005yrs. Follow-up is necessary to confirm whether the intervention can actually prevent the development of asthma.<\/jats:p>","DOI":"10.1183\/09031936.05.00067704","type":"journal-article","created":{"date-parts":[[2005,3,31]],"date-time":"2005-03-31T18:23:29Z","timestamp":1112293409000},"page":"660-670","source":"Crossref","is-referenced-by-count":64,"title":["The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma"],"prefix":"10.1183","volume":"25","author":[{"given":"H. J. A. 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