{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:21:17Z","timestamp":1790767277065,"version":"4.1.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,10,15]]},"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>The dual endothelin receptor antagonist bosentan has been approved in several countries for pulmonary arterial hypertension, and patients with portopulmonary hypertension (PPHTN) have not specifically been excluded. However, no data have been published on the efficacy and safety of bosentan in this patient population. Here, the first clinical experiences with bosentan in patients with Child A cirrhosis and severe PPHTN are reported.<\/jats:p><jats:p>In total, 11 consecutive patients with cirrhosis and severe PPHTN in New York Heart Association Functional Classes III and IV were treated for &gt;1\u2005yr with bosentan.<\/jats:p><jats:p>After 1\u2005yr of treatment with bosentan, all patients showed improved symptoms and exercise capacity. The 6-min walking distance increased from 310\u00b1102\u2005m at baseline to 388\u00b181\u2005m at 1\u2005yr. Cardiopulmonary exercise testing disclosed a significant increase in peak oxygen uptake, from 12.6\u00b13.5 to 16.6\u00b12.8\u2005mL\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup>. Pulmonary vascular resistance fell from 944\u00b1519 to 635\u00b1321\u2005dynes\u00b7s\u00b7L<jats:sup>\u22121<\/jats:sup>. The medication was well tolerated by all patients, and there was no evidence of drug-related liver injury.<\/jats:p><jats:p>In conclusion, bosentan proved to be efficacious and safe in a small number of patients with portopulmonary hypertension.<\/jats:p>","DOI":"10.1183\/09031936.05.00080804","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T19:59:19Z","timestamp":1109620759000},"page":"502-508","source":"Crossref","is-referenced-by-count":162,"title":["Bosentan therapy for portopulmonary hypertension"],"prefix":"10.1183","volume":"25","author":[{"given":"M. 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