{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:37:32Z","timestamp":1774125452342,"version":"3.50.1"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,11,12]]},"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>Optimal management of nonsmall cell lung cancer (NSCLC) depends on tissue diagnosis and accurate staging. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is minimally invasive and provides cytological confirmation of malignant mediastinal disease. The aim was to assess the accuracy of EUS-FNA in cases of enlarged mediastinal lymphadenopathy (LN) of unknown aetiology and in the staging of NSCLC.<\/jats:p><jats:p>A total of 52 consecutive patients with stage I\u2013IIIb NSCLC or enlarged mediastinal LN of unknown aetiology underwent EUS-FNA. Negative results were confirmed with a surgical procedure: mediastinoscopy, video-assisted thoracic surgery (VATS) or lobectomy with systematic mediastinal lymph node dissection.<\/jats:p><jats:p>In total, 34 patients had EUS-FNA performed for diagnosis, whilst the remaining 18 had EUS-FNA for staging. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy (95% confidence interval) were 93% (77\u201399), 100% (78\u2013100), 100% (87\u2013100), 88% (63\u201399) and 95% (84\u201399), respectively. When EUS-FNA was used in patients with NSCLC, the sensitivity, specificity, PPV, NPV and accuracy were 92% (73\u201399), 100% (69\u2013100), 100% (85\u2013100), 83% (51\u201398) and 94% (80\u201399), respectively. For mediastinal LN of unknown aetiology, no malignant disease was missed.<\/jats:p><jats:p>Endoscopic ultrasound-guided fine-needle aspiration is an accurate tool for assessing mediastinal lymph node involvement in nonsmall cell lung cancer and in the diagnosis of unexplained mediastinal lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration is a minimally invasive procedure that can be used as an adjunct or alternative to mediastinoscopy.<\/jats:p>","DOI":"10.1183\/09031936.05.00092104","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T19:59:19Z","timestamp":1109620759000},"page":"410-415","source":"Crossref","is-referenced-by-count":46,"title":["The accuracy of EUS-FNA in assessing mediastinal lymphadenopathy and staging patients with NSCLC"],"prefix":"10.1183","volume":"25","author":[{"given":"G.","family":"Caddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Conron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Desmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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