{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:09:20Z","timestamp":1782925760031,"version":"3.54.5"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2004,11,6]]},"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>The objective of the current study was to assess the yield of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for the diagnosis of sarcoidosis in a large patient group.<\/jats:p><jats:p>Bronchoscopy with transbronchial lung biopsy (TBLB) is nondiagnostic in 30% of patients with suspected sarcoidosis and has a risk of pneumothorax and haemoptysis. In order to obtain a diagnosis, mediastinoscopy is often performed as the next diagnostic procedure. EUS-FNA provides a nonsurgical alternative for the demonstration of noncaseating granulomas by aspirating mediastinal lymph nodes from the oesophagus.<\/jats:p><jats:p>In total, 51 patients with suspected sarcoidosis stage \u2592 and \u2592\u2592 underwent EUS-FNA. Thirty-six patients (71%) previously underwent a nondiagnostic bronchoscopy. All patients were clinically followed (median 18 months) and surgical\u2013pathological verification occurred in those patients with EUS aspirates that contained unrepresentative material.<\/jats:p><jats:p>EUS-FNA demonstrated noncaseating granulomas without necrosis in 41 of 50 patients (82%) with the final diagnosis of sarcoidosis. Specific ultrasound features of clustered, well-demarcated iso-echoic lymph nodes were observed in 64% of patients with sarcoidosis. No complications occurred.<\/jats:p><jats:p>Endoscopic ultrasound-guided fine-needle aspiration has a high yield in diagnosing sarcoidosis and qualifies as the next diagnostic step after a nondiagnostic bronchoscopy. The current authors expect that endoscopic ultrasound-guided fine-needle aspiration will reduce the number of mediastinoscopies for the diagnosis of sarcoidosis dramatically.<\/jats:p>","DOI":"10.1183\/09031936.05.00098404","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T19:59:19Z","timestamp":1109620759000},"page":"405-409","source":"Crossref","is-referenced-by-count":119,"title":["Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis"],"prefix":"10.1183","volume":"25","author":[{"given":"J. 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