{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:05:03Z","timestamp":1791219903399,"version":"4.1.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2005,1,27]]},"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>This is the first prospective clinical trial in which patients with acute bacterial exacerbation of chronic bronchitis have been stratified by degree of underlying illness.<\/jats:p><jats:p>Uncomplicated patients were randomised to levofloxacin 750\u2005mg once daily (<jats:italic>q.d.<\/jats:italic>) for 3 days or azithromycin<jats:italic>q.d.<\/jats:italic>for 5 days. Complicated patients were randomised to levofloxacin 750\u2005mg<jats:italic>q.d.<\/jats:italic>for 5 days or amoxicillin 875\u2005mg\/clavulanate 125\u2005mg twice daily for 10 days.<\/jats:p><jats:p>Regardless of therapy, complicated patients demonstrated lower clinical and microbiological success than uncomplicated patients. Clinical success for clinically evaluable patients was similar for levofloxacin and azithromycin (93.0<jats:italic>versus<\/jats:italic>90.1%, respectively), and levofloxacin and amoxicillin\/clavulanate (79.2<jats:italic>versus<\/jats:italic>81.7%, respectively). For microbiologically evaluable patients, clinical response to levofloxacin for 3 days was superior to azithromycin for 5 days (96.3<jats:italic>versus<\/jats:italic>87.4%, respectively), and levofloxacin for 5 days was similar to amoxicillin\/clavulanate for 10 days (81.4<jats:italic>versus<\/jats:italic>80.9%, respectively). Microbiological eradication was superior for levofloxacin for 3 days compared with azithromycin for 5 days (93.8<jats:italic>versus<\/jats:italic>82.8%, respectively), and similar for levofloxacin and amoxicillin\/clavulanate for 10 days (81.4<jats:italic>versus<\/jats:italic>79.8%, respectively).<\/jats:p><jats:p>In conclusion, levofloxacin 750\u2005mg for 3 days was comparable to azithromycin for 5 days for uncomplicated patients with acute bacterial exacerbation of chronic bronchitis, while 5 days of 750\u2005mg levofloxacin was comparable to 10 days of amoxicillin\/clavulanate for complicated acute bacterial exacerbation of chronic bronchitis.<\/jats:p>","DOI":"10.1183\/09031936.05.00106404","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T03:04:22Z","timestamp":1117595062000},"page":"1001-1010","source":"Crossref","is-referenced-by-count":33,"title":["Patient stratification in the management of acute bacterial exacerbation of chronic bronchitis: the role of levofloxacin 750\u2005mg"],"prefix":"10.1183","volume":"25","author":[{"given":"F. 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