{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:24:57Z","timestamp":1770279897432,"version":"3.49.0"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,3,29]]},"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>The aim of the present study was to compare the direct costs of three models for detection of latent tuberculosis infection (LTBI) in routine clinical practice in Switzerland.<\/jats:p><jats:p>Comparison of the overall costs of screening for LTBI, including medical and radiological examination, and preventive treatment associated with three screening models was carried out. Model 1 relies only on the tuberculin skin test (TST) according to the current national guidelines, model 2 relies on T-SPOT\u00ae.<jats:italic>TB<\/jats:italic>(Oxford Immunotec, Oxford, UK) only and model 3 relies on TST followed by confirmation of positive results by T-SPOT.<jats:italic>TB<\/jats:italic>. Costs were taken directly from the clinic's figures. Clinical assumptions were based on the 267 patients who were referred to the clinic over the study period.<\/jats:p><jats:p>Model 3 was found to be the most cost-effective. Using only the skin test (model 1) was the least cost-effective. If only one test for LTBI is to be used, then model 2 (using T-SPOT.<jats:italic>TB<\/jats:italic>only) is cheaper than using the TST (model 1).<\/jats:p><jats:p>Screening for latent tuberculosis infection by tuberculin skin test followed by confirmation with T-SPOT.<jats:italic>TB<\/jats:italic>is less costly than screening with tuberculin skin test alone, as it allows a reduction in the number of people who receive preventive treatment. In groups with a high proportion of negative tuberculin skin tests, screening with T-SPOT.<jats:italic>TB<\/jats:italic>test only may be the most cost-effective.<\/jats:p>","DOI":"10.1183\/09031936.06.00005906","type":"journal-article","created":{"date-parts":[[2006,4,13]],"date-time":"2006-04-13T00:15:30Z","timestamp":1144887330000},"page":"45-50","source":"Crossref","is-referenced-by-count":62,"title":["Direct costs of three models for the screening of latent tuberculosis infection"],"prefix":"10.1183","volume":"28","author":[{"given":"P.","family":"Wrighton-Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-P.","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2006,4,12]]},"reference":[{"key":"2024102019031948000_28.1.45.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00261402"},{"key":"2024102019031948000_28.1.45.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2009100"},{"key":"2024102019031948000_28.1.45.3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1164\/ajrccm.163.4.ed0201c","volume":"163","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102019031948000_28.1.45.4","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.11.916"},{"key":"2024102019031948000_28.1.45.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"2024102019031948000_28.1.45.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"2024102019031948000_28.1.45.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05115-1"},{"key":"2024102019031948000_28.1.45.8","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200211220-00008"},{"key":"2024102019031948000_28.1.45.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12950-9"},{"key":"2024102019031948000_28.1.45.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-307OC"},{"key":"2024102019031948000_28.1.45.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-9-200405040-00010"},{"key":"2024102019031948000_28.1.45.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17592-2"},{"key":"2024102019031948000_28.1.45.13","first-page":"1242","volume":"9","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102019031948000_28.1.45.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1377-8"},{"key":"2024102019031948000_28.1.45.15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-748OC"},{"key":"2024102019031948000_28.1.45.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67534-4"},{"key":"2024102019031948000_28.1.45.17","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000191923.08938.5b"},{"key":"2024102019031948000_28.1.45.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-179OC"},{"key":"2024102019031948000_28.1.45.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"2024102019031948000_28.1.45.20","unstructured":"Ligue pulmonaire suisse et Office f\u00e9d\u00e9ral de la sant\u00e9 publique. 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