{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:28:44Z","timestamp":1790378924893,"version":"4.1.0"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,3,10]]},"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>The aim of the present study was to perform cost-minimisation analysis of contact investigation from a public health perspective using the tuberculin skin test (TST) and a new blood assay, QuantiFERON-TB Gold (QFT-G).<\/jats:p><jats:p>A decision-analysis model simulated the costs of investigating a cohort of adult close tuberculosis contacts by the public health service following the current German guidelines over a period of 2\u2005yrs. The economic outcomes were compared with alternative screening strategies. These were: 1) QFT-G instead of TST; 2) TST followed by QFT-G; and 3) TST followed by QFT-G in vaccinated (bacille Calmette\u2013Gu\u00e9rin (BCG)) subjects.<\/jats:p><jats:p>In a base-case analysis, the costs of TST-based screening were 91.06\u2005Euros (EUR)\u00b7contact<jats:sup>-1<\/jats:sup>, assuming a 1% tuberculosis-case-finding incidence. The least expensive strategy was TST screening plus subsequent QFT-G testing (52.05\u2005EUR), resulting in a 43% cost reduction. Using QFT-G alone in BCG-vaccinated subjects who tested positive in the TST led to a 39% cost reduction. The savings using QFT-G alone instead of TST amounted to 29.77\u2005EUR\u00b7contact<jats:sup>-1<\/jats:sup>. The results depended on the acquisition costs assumed and the proportion of positive results in TST-based screening.<\/jats:p><jats:p>Screening for tuberculosis by combining tuberculin skin testing and QuantiFERON-TB Gold markedly reduces public health costs compared with tuberculin skin test screening alone.<\/jats:p>","DOI":"10.1183\/09031936.06.00011806","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T01:13:36Z","timestamp":1143681216000},"page":"35-44","source":"Crossref","is-referenced-by-count":66,"title":["Cost-optimisation of screening for latent tuberculosis in close contacts"],"prefix":"10.1183","volume":"28","author":[{"given":"R.","family":"Diel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nienhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Schaberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"2024102019004904000_28.1.35.1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1050(200007)9:5<411::AID-HEC524>3.0.CO;2-9"},{"key":"2024102019004904000_28.1.35.2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1164\/ajrccm.162.6.2001111","volume":"162","year":"2000","journal-title":"Am J Crit Care Med"},{"key":"2024102019004904000_28.1.35.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa031667"},{"key":"2024102019004904000_28.1.35.4","first-page":"1","volume":"19","year":"1976","journal-title":"Adv Tuberc Res"},{"key":"2024102019004904000_28.1.35.5","first-page":"1","volume":"54","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"2024102019004904000_28.1.35.6","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.887"},{"key":"2024102019004904000_28.1.35.7","first-page":"657","volume":"58","year":"1996","journal-title":"Gesundheitswesen"},{"key":"2024102019004904000_28.1.35.8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-812527"},{"key":"2024102019004904000_28.1.35.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00047805"},{"key":"2024102019004904000_28.1.35.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05115-1"},{"key":"2024102019004904000_28.1.35.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12950-9"},{"key":"2024102019004904000_28.1.35.12","first-page":"1242","volume":"9","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102019004904000_28.1.35.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"2024102019004904000_28.1.35.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-179OC"},{"key":"2024102019004904000_28.1.35.15","first-page":"1623","volume":"118","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2024102019004904000_28.1.35.16","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(78)90002-8"},{"key":"2024102019004904000_28.1.35.17","first-page":"28","volume":"18","year":"1970","journal-title":"Adv Tuberc Res"},{"key":"2024102019004904000_28.1.35.18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1164\/ajrccm.158.2.9801062","volume":"158","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102019004904000_28.1.35.19","unstructured":"Swiss Lung League. 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