{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:50:25Z","timestamp":1773399025470,"version":"3.50.1"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2005,11,15]]},"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire.\n                  <\/jats:p>\n                  <jats:p>\n                    The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO\n                    <jats:sub>2<\/jats:sub>\n                    and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age.\n                  <\/jats:p>\n                  <jats:p>\n                    The incidence rate for asthma among sulphite mill workers reporting gassings of SO\n                    <jats:sub>2<\/jats:sub>\n                    was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO\n                    <jats:sub>2<\/jats:sub>\n                    and any gassings (HR (95% CI) 4.0 (2.1\u20137.7)). Among males reporting gassings to SO\n                    <jats:sub>2<\/jats:sub>\n                    , the HR (95% CI) for asthma was 5.8 (2.6\u201313) compared with unexposed males.\n                  <\/jats:p>\n                  <jats:p>In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.<\/jats:p>","DOI":"10.1183\/09031936.06.00034305","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T09:18:35Z","timestamp":1144055915000},"page":"720-725","source":"Crossref","is-referenced-by-count":54,"title":["Incidence of asthma among workers exposed to sulphur dioxide and other irritant 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