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The current authors hypothesised that the<jats:italic>-1082GG<\/jats:italic>genotype is associated with the development of, and outcomes in, acute respiratory distress syndrome (ARDS).<\/jats:p><jats:p>A nested case\u2013control study was conducted in 211 Caucasian cases of ARDS and 429 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for organ failure and 60-day mortality.<\/jats:p><jats:p>The<jats:italic>-1082GG<\/jats:italic>genotype was associated with the development of ARDS, but only in the presence of a significant interaction between the<jats:italic>-1082GG<\/jats:italic>genotype and age. Among patients with ARDS, the<jats:italic>-1082GG<\/jats:italic>genotype was associated with decreased severity of illness on admission, lower daily organ dysfunction scores and lower 60-day mortality.<\/jats:p><jats:p>In conclusion, the high interleukin-10-producing<jats:italic>-1082GG<\/jats:italic>genotype may be associated with variable odds for acute respiratory distress syndrome development depending on age. Among those with acute respiratory distress syndrome, the<jats:italic>-1082GG<\/jats:italic>genotype is associated with lower mortality and organ failure. Further studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1183\/09031936.06.00046405","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T13:18:35Z","timestamp":1144070315000},"page":"674-681","source":"Crossref","is-referenced-by-count":87,"title":["Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome"],"prefix":"10.1183","volume":"27","author":[{"given":"M. N.","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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