{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:47:11Z","timestamp":1792608431249,"version":"4.5.0"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2005,8,23]]},"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension that affects predominantly post-capillary pulmonary vessels. A major concern with PVOD is the poor response to available therapies and the risk of pulmonary oedema with continuous intravenous epoprostenol.<\/jats:p>\n                  <jats:p>The present authors hypothesised that alveolar haemorrhage may be a characteristic feature of pulmonary veno-occlusive disease, as compared with other forms of pulmonary arterial hypertension that predominantly involve pre-capillary pulmonary arteries.<\/jats:p>\n                  <jats:p>\n                    This paper reports a series of 19 patients with either PVOD (n\u200a=\u200a8) or idiopathic pulmonary arterial hypertension (IPAH; n\u200a=\u200a11) who underwent bronchoalveolar lavage. Cytological analyses were performed and differential counts were made on Perls-stained preparations. The Golde score was used to assess alveolar haemorrhage. As compared with IPAH, PVOD was characterised by a higher percentage of haemosiderin-laden macrophages (40\u00b137\n                    <jats:italic>versus<\/jats:italic>\n                    3\u00b16%), resulting in elevated Golde scores (81\u00b188\n                    <jats:italic>versus<\/jats:italic>\n                    4\u00b110).\n                  <\/jats:p>\n                  <jats:p>It was concluded that occult alveolar haemorrhage is a common feature of pulmonary veno-occlusive disease. Detecting occult alveolar haemorrhage may be of interest in the diagnostic approach of pulmonary veno-occlusive disease.<\/jats:p>","DOI":"10.1183\/09031936.06.00054105","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T13:12:42Z","timestamp":1135948362000},"page":"108-113","source":"Crossref","is-referenced-by-count":126,"title":["Occult alveolar haemorrhage in pulmonary veno-occlusive 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