{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:52:24Z","timestamp":1791478344642,"version":"4.3.4"},"reference-count":46,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,2,14]]},"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Although sleep apnoea is very common in patients with end-stage renal disease, the physiological mechanisms for this association have not yet been determined. The current authors hypothesised that altered respiratory chemo-responsiveness may play an important role.<\/jats:p>\n                  <jats:p>\n                    In total, 58 patients receiving treatment with chronic dialysis were recruited for overnight polysomnography. A modified Read rebreathing technique, which is used to assess basal ventilation, ventilatory sensitivity and threshold, was completed before and after overnight polysomnography. Patients were divided into apnoeic (n\u200a=\u200a38; apnoea\/hypopnoea index (AHI) 35\u00b122 events\u00b7h\n                    <jats:sup>-1<\/jats:sup>\n                    ) and nonapnoeic (n\u200a=\u200a20; AHI 3\u00b13 events\u00b7h\n                    <jats:sup>-1<\/jats:sup>\n                    ) groups, with the presence of sleep apnoea defined as an AHI &gt;10 events\u00b7h\n                    <jats:sup>-1<\/jats:sup>\n                    . While basal ventilation and the ventilatory recruitment threshold were similar between groups, ventilatory sensitivity during isoxic hypoxia (partial pressure of oxygen (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    ) 6.65 kPa) and hyperoxia (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    19.95 kPa) was significantly greater in apnoeic patients. Overnight changes in chemoreflex responsiveness were similar between groups.\n                  <\/jats:p>\n                  <jats:p>In conclusion, these data indicate that the responsiveness of both the central and peripheral chemoreflexes is augmented in patients with sleep apnoea and end-stage renal disease. Since increased ventilatory sensitivity to hypercapnia destabilises respiratory control, the current authors suggest this contributes to the pathogenesis of sleep apnoea in this patient population.<\/jats:p>","DOI":"10.1183\/09031936.06.00075405","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T20:13:29Z","timestamp":1141244009000},"page":"151-158","source":"Crossref","is-referenced-by-count":114,"title":["Enhanced chemo-responsiveness in patients with sleep apnoea and end-stage renal disease"],"prefix":"10.1183","volume":"28","author":[{"given":"J.","family":"Beecroft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Duffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pierratos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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