{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:28:07Z","timestamp":1788874087870,"version":"build-2803163510"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,2,7]]},"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Bacille Calmette\u2013Gu\u00e9rin (BCG) vaccination can confound tuberculin skin test (TST) reactions in the diagnosis of latent tuberculosis infection (LTBI).<\/jats:p><jats:p>The TST was compared with a<jats:italic>Mycobacterium tuberculosis<\/jats:italic>(MTB)-specific enzyme-linked immunospot (ELISPOT) assay during an outbreak of MTB infection at a police academy in Germany.<\/jats:p><jats:p>Participants were grouped according to their risk of LTBI in close (n\u200a=\u200a36) or occasional (n\u200a=\u200a333) contacts to the index case. For the TST, the positive response rate was 53% (19 out of 36) among close and 16% (52 out of 333) among occasional contacts. In total, 56 TST-positive contacts (56 out of 71\u200a=\u200a78.9%) and 27 TST-negative controls (27 out of 298\u200a=\u200a9.1%) underwent ELISPOT testing. The odds ratio (OR) of a positive test result across the two groups was 29.2 (95% confidence interval (CI) 3.5\u2013245.0) for the ELISPOT and 19.7 (95% CI 2.0\u2013190.2) for the TST with a 5\u2005mm cut-off. Of 369 contacts, 158 (42.8%) had previously received BCG vaccination. The overall agreement between the TST and the ELISPOT was low, and positive TST reactions were confounded by BCG vaccination (OR 4.8 (95% CI 1.3\u201318.0)). In contrast, use of a 10-mm induration cut-off for the TST among occasional contacts showed strong agreement between TST and ELISPOT in nonvaccinated persons.<\/jats:p><jats:p>In bacille Calmette\u2013Gu\u00e9rin-vaccinated individuals, the<jats:italic>Mycobacterium tuberculosis<\/jats:italic>-specific enzyme-linked immunospot assay is a better indicator for the risk of latent tuberculosis infection than the tuberculin skin test.<\/jats:p>","DOI":"10.1183\/09031936.06.00107005","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T01:33:32Z","timestamp":1140053612000},"page":"16-23","source":"Crossref","is-referenced-by-count":45,"title":["Avoiding the effect of BCG vaccination in detecting<i>Mycobacterium tuberculosis<\/i>infection with a blood test"],"prefix":"10.1183","volume":"28","author":[{"given":"R.","family":"Diel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"D\u00f6scher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Visuri-Karbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Greinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nienhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2006,2,15]]},"reference":[{"key":"2024102018584926000_28.1.16.1","first-page":"133","volume":"50","year":"2003","journal-title":"Ind J Tub"},{"key":"2024102018584926000_28.1.16.2","unstructured":"Global tuberculosis control: surveillance, planning, financing. 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