{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:34:59Z","timestamp":1774125299880,"version":"3.50.1"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,2,27]]},"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>The aim of this study was to compare the performance of the T-SPOT.<jats:italic>TB<\/jats:italic><jats:sup>TM<\/jats:sup>test, a T-cell-based test, with the tuberculin skin test (TST) in the diagnosis of latent tuberculosis (TB) infection.<\/jats:p><jats:p>The study was carried out in 138 immunosuppressed haematology patients who had been nosocomially exposed to a case of smear-positive TB.<\/jats:p><jats:p>Overall, 44.2% of the contacts were positive by T-SPOT.<jats:italic>TB<\/jats:italic><jats:sup>TM<\/jats:sup>test, and 17.4% by TST (concordance 67.8%). The apparent prevalence of infection fell from 25.9 to 14.5% with the TST with increasing immunosuppression, although this difference was not significant. In contrast, the apparent prevalence of infection with the T-SPOT.<jats:italic>TB<\/jats:italic><jats:sup>TM<\/jats:sup>test was unaffected at 44.6 and 44.3%, respectively. The T-SPOT.<jats:italic>TB<\/jats:italic><jats:sup>TM<\/jats:sup>test had an overall indeterminate rate of 4.3%, and this was also unaffected by the level of immunosuppression.<\/jats:p><jats:p>This study suggests that the T-SPOT.<jats:italic>TB<\/jats:italic><jats:sup>TM<\/jats:sup>test maintains its sensitivity and performance in immunocompromised patients, identifying a large number of truly infected patients anergic to the tuberculin skin test.<\/jats:p>","DOI":"10.1183\/09031936.06.00110205","type":"journal-article","created":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T01:24:27Z","timestamp":1142472267000},"page":"31-34","source":"Crossref","is-referenced-by-count":89,"title":["Use of a T-cell-based test for detection of tuberculosis infection among immunocompromised patients: Table 1\u2014"],"prefix":"10.1183","volume":"28","author":[{"given":"F.","family":"Piana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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