{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:06:11Z","timestamp":1790867171355,"version":"4.1.0"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,6,23]]},"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>A retrospective study was performed to determine factors associated with the outcome of pulmonary multidrug-resistant tuberculosis (MDR-TB) in Taipei, Taiwan.<\/jats:p><jats:p>All patients newly diagnosed with pulmonary MDR-TB in a referral centre from 1992\u20131996 were enrolled and their outcome over the subsequent 6 yrs was determined.<\/jats:p><jats:p>A total of 299 patients were identified, comprising 215 (71.9%) males and 84 (28.1%) females with a mean age of 47.3 yrs. The patients received a mean of 3.7 effective drugs. Out of the 299 patients, 153 (51.2%) were cured, 31 (10.4%) failed, 28 (9.4%) died and 87 (29.1%) defaulted. Of the 125 patients receiving second-line drugs with ofloxacin, 74 (59.2%) were cured. Those who received ofloxacin had a lower risk of relapse than those receiving only first-line drugs (hazard ratio (HR) 0.16, 95% confidence interval (CI) 0.03\u20130.81) and a lower risk of TB-related death than those receiving second-line drugs but not ofloxacin (adjusted HR 0.50, 95% CI 0.31\u20130.82).<\/jats:p><jats:p>In conclusion, multidrug-resistant tuberculosis patients who received ofloxacin were more likely to be cured, and were less likely to die, fail or relapse. The utility of new-generation fluoroquinolones, such as moxifloxacin, in the treatment of multidrug-resistant tuberculosis needs to be evaluated. Default from treatment is a major challenge in the treatment of multidrug-resistant tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.06.00125705","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T00:39:11Z","timestamp":1152751151000},"page":"980-985","source":"Crossref","is-referenced-by-count":86,"title":["Outcome of pulmonary multidrug-resistant tuberculosis: a 6-yr follow-up study"],"prefix":"10.1183","volume":"28","author":[{"given":"C-Y.","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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