{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:54:56Z","timestamp":1775087696724,"version":"3.50.1"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,6,30]]},"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>The aim of the present study was to determine the effects of mechanical ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung injury.<\/jats:p><jats:p>In a randomised controlled trial, Sprague\u2013Dawley rats (n\u200a=\u200a61) were allocated to three ventilation groups after intratracheal LPS (<jats:italic>Salmonella enteritidis<\/jats:italic>) instillations. Group I animals were subjected to 16\u2005cmH<jats:sub>2<\/jats:sub>O positive inspiratory pressure (PIP) and 5\u2005cmH<jats:sub>2<\/jats:sub>O positive end-expiratory pressure (PEEP); group II animals to 26\u2005cmH<jats:sub>2<\/jats:sub>O PIP and 5\u2005cmH<jats:sub>2<\/jats:sub>O PEEP; and group III animals to 35\u2005cmH<jats:sub>2<\/jats:sub>O PIP and 5\u2005cmH<jats:sub>2<\/jats:sub>O PEEP. Control rats (not mechanically ventilated) received LPS. Healthy rats served as a reference group. Levels of thrombin\u2013antithrombin complex (TATc),<jats:sc>D<\/jats:sc>-dimer, plasminogen activator inhibitor (PAI) activity and PAI-1 antigen in bronchoalveolar lavage fluid were measured.<\/jats:p><jats:p>LPS-induced lung injury increased TATc,<jats:sc>D<\/jats:sc>-dimer and PAI activity and PAI-1 antigen levels<jats:italic>versus<\/jats:italic>healthy animals. High pressure-amplitude ventilation increased TATc concentrations.<jats:sc>D<\/jats:sc>-dimer concentrations were not significantly raised. Instead, PAI activity increased with the amplitude of the pressure, from 0.7\u2005U\u00b7mL<jats:sup>-1<\/jats:sup>in group I to 3.4\u2005U\u00b7mL<jats:sup>-1<\/jats:sup>in group II and 5.0\u2005U\u00b7mL<jats:sup>-1<\/jats:sup>in group III. There was no change in PAI-1 antigen levels.<\/jats:p><jats:p>In conclusion, mechanical ventilation creates an alveolar\/pulmonary anti-fibrinolytic milieu in endotoxin-induced lung injury which, at least in part, might be due to an increase in plasminogen activator inhibitor activity.<\/jats:p>","DOI":"10.1183\/09031936.06.00133104","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T00:39:11Z","timestamp":1152751151000},"page":"992-998","source":"Crossref","is-referenced-by-count":21,"title":["Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury"],"prefix":"10.1183","volume":"28","author":[{"given":"P.","family":"Dahlem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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