{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:52:00Z","timestamp":1790034720532,"version":"4.0.1"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"published-print":{"date-parts":[[1995,2,1]]},"abstract":"<jats:p>The gamma aminobutyric acid (GABA)-B agonist, baclofen, is a centrally-acting, anti-spasmodic agent and muscle relaxant used in spinal cord lesions, multiple sclerosis and other neurological disorders. In a previous pilot study of quadriplegic patients, 75% of whom were treated with baclofen, we found a high prevalence of sleep-disordered breathing. Because of the depressant effects of GABA on the central nervous system, we hypothesized that baclofen might aggravate sleep-disordered breathing in susceptible individuals by depressing central ventilatory drive, increasing upper airway obstruction and\/or increasing the arousal threshold to apnoea. We therefore conducted a double-blind, placebo-controlled, cross-over study of baclofen 25 mg, administered before sleep in 10 snorers with mild sleep-disordered breathing (respiratory disturbance index &lt; 30 events per sleep hour). Each subject underwent two standard polysomnographic assessments, one week apart. Total sleep time was significantly prolonged by baclofen (placebo 356 +\/- 9.9 SEM min; baclofen 386 +\/- 9.9 min). Both nonrapid eye movement(REM) and REM sleep duration were increased (nonREM: placebo 295 +\/- 6.8 min; baclofen 311 +\/- 8.9 min; REM: placebo 61 +\/- 7.5 min; baclofen 76 +\/- 9.0 min). Time spent awake after sleep onset was reduced after baclofen (placebo 71 +\/- 10.3 min; baclofen 51 +\/- 9.7 min). There was a slight reduction in mean overnight oxygen saturation (placebo 95.2 +\/- 0.5%; baclofen 94.4 +\/- 0.7%). The frequency of apnoeas plus hypopnoeas (respiratory disturbance index (RDI)) did not change significantly (placebo 9 +\/- 1.8 events.h-1; baclofen 13 +\/- 3.4 events.h-1).(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1183\/09031936.95.08020230","type":"journal-article","created":{"date-parts":[[2003,9,25]],"date-time":"2003-09-25T19:48:02Z","timestamp":1064519282000},"page":"230-234","source":"Crossref","is-referenced-by-count":76,"title":["The effects of the GABA agonist, baclofen, on sleep and breathing"],"prefix":"10.1183","volume":"8","author":[{"given":"AJ","family":"Finnimore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sajkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RD","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[1995,2,1]]},"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.95.08020230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:27:04Z","timestamp":1740382024000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.95.08020230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,2,1]]},"published-print":{"date-parts":[[1995,2,1]]}},"alternative-id":["10.1183\/09031936.95.08020230"],"URL":"https:\/\/doi.org\/10.1183\/09031936.95.08020230","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2,1]]}}}