{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:17:28Z","timestamp":1774567048676,"version":"3.50.1"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p>This study was designed to investigate the pathogenesis of chlorine gas (Cl2) induced acute lung injury and oedema. Isolated blood-perfused rabbit lungs were ventilated either with air (n=7) or air plus 500 parts per million (ppm) of Cl2 (n=7) for 10 min. Capillary pressure, measured by analysing the pressure\/time transients of pulmonary arterial, venous and double (both arterial and venous) occlusions, was unchanged in both groups. In Cl2-exposed lungs, the fluid filtration rate increased from -0.228+\/-0.25 to 1.823+\/-1.23 mL min(-1) x 100 g(-1) (p&lt;0.001) and the filtration coefficient increased from 0.091+\/-0.01 to 0.259+\/-0.07 mL x min(-1) x cmH2O(-1) x 100 g(-1) (p&lt;0.001). No changes were observed in the control lungs. The extravascular lung water\/blood-free dry weight ratio was 8.6+\/-1.6 in the Cl2 group and 4.0+\/-0.5 in the control group (p&lt;0.001), confirming that the increase in lung weight was related to accumulation of extravascular fluid. Although the alveolar flooding by oedema is explained, in part, by the Cl2-induced epithelial injury, our results suggest that Cl2 exposure induces acute lung injury and oedema due to an increased microvascular permeability.<\/jats:p>","DOI":"10.1183\/09031936.97.10051100","type":"journal-article","created":{"date-parts":[[2003,2,27]],"date-time":"2003-02-27T01:54:34Z","timestamp":1046310874000},"page":"1100-1107","source":"Crossref","is-referenced-by-count":23,"title":["Chlorine gas induced acute lung injury in isolated rabbit lung"],"prefix":"10.1183","volume":"10","author":[{"given":"A","family":"Menaouar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Anglade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Baussand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pelloux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Corboz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lantuejoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Benchetrit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FA","family":"Grimbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[1997,5,1]]},"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.97.10051100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:15:17Z","timestamp":1740381317000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.97.10051100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1997,5,1]]},"published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1183\/09031936.97.10051100"],"URL":"https:\/\/doi.org\/10.1183\/09031936.97.10051100","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}