{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:19:46Z","timestamp":1787019586584,"version":"build-2736575974"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"published-print":{"date-parts":[[1997,6,1]]},"abstract":"<jats:p>Acute severe asthma, or \"status asthmaticus\", is a devastating clinical condition ultimately resulting in life-threatening hypoxaemia. The pivotal intrapulmonary mechanism of this condition is profound ventilation\/perfusion (V'A\/Q') mismatch, characterized by a predominant bimodal blood flow pattern reflecting a marked deterioration (increase) of the dispersion of pulmonary blood flow. This V'A\/Q' profile is consistent with the presence of numerous alveolar units with low V'A\/Q' ratios, in which ventilation is markedly reduced, although never abolished, but perfusion is maintained. Further V'A\/Q' worsening whilst breathing 100% O2 suggests the presence of an underlying vigorous hypoxic vascular response. Of equal importance, gas exchange disturbances are poorly related to the severity of reduced maximal airflow rates. Inhaled platelet-activating factor (PAF), both in normal individuals and asthmatic patients, results in moderate-to-severe disturbance of V'A\/Q' status, a finding that is probably related to altered microvascular permeability within the airway wall. Salbutamol, but not ipratropium bromide, prevented all PAF-induced systemic and lung function abnormalities, possibly because venoconstriction in the bronchial circulation was antagonized. Taken together, these findings support the hypothesis that platelet-activating factor may play a critical role in the pathobiology of severe acute exacerbations of asthma.<\/jats:p>","DOI":"10.1183\/09031936.97.10061359","type":"journal-article","created":{"date-parts":[[2003,2,28]],"date-time":"2003-02-28T17:18:34Z","timestamp":1046452714000},"page":"1359-1371","source":"Crossref","is-referenced-by-count":61,"title":["Acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities"],"prefix":"10.1183","volume":"10","author":[{"given":"R","family":"Rodriguez-Roisin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[1997,6,1]]},"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.97.10061359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:40:10Z","timestamp":1740364810000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.97.10061359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1997,6,1]]},"published-print":{"date-parts":[[1997,6,1]]}},"alternative-id":["10.1183\/09031936.97.10061359"],"URL":"https:\/\/doi.org\/10.1183\/09031936.97.10061359","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6,1]]}}}