{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:18:21Z","timestamp":1740460701291,"version":"3.37.3"},"reference-count":0,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:p>The effects of high pulmonary blood flow and pressure on pulmonary development are well understood, but the effect of low pulmonary flow\/pressure is not. Pulmonary stenosis (PS) was therefore used as a model to determine its effect on lung development, which was assessed noninvasively by carbon monoxide transfer at rest and during exercise. One hundred and six control children (55 males, 8-16 yrs) and 11 children with isolated valvar or subvalvar PS surgically corrected &gt; or =10 yrs prior to the study without residual stenosis\/regurgitation were evaluated. Measurements of effective pulmonary blood flow, stroke volume, arteriovenous oxygen difference (AVO), transfer factor and transfer constant, alveolar ventilation and anaerobic threshold were performed using a mass spectrometer. Data from the normal children allowed calculation of z-scores for the study group matched for age, sex, pubertal stage and surface area. PS children at rest had a significantly lower forced expired volume in one second, cardiac frequency and transfer constant with a raised oxygen consumption and AVO which persisted on exercise. During exercise, the cardiac frequency was 12 beats x min(-1) slower and AVO 0.017 L greater than controls (p&lt;0.05). A persistently mildly raised effective functional residual capacity (0.2 L x m(-2)) during exercise led to a reduced transfer constant (0.35 mmol x min(-1) x kPa(-1) x L(-1)), although the percentage rise (28%) from rest to peak exercise was normal. The percentage fall in stroke volume from the penultimate exercise stage to peak exercise stage was greater in PS children (24%, 95% confidence interval 11-37) than control children (2.4, -2-10, p&lt;0.005). In conclusion, although the effects are small, pulmonary stenosis does affect cardiopulmonary function after surgery. This needs to be considered when contemplating the timing of treatment.<\/jats:p>","DOI":"10.1183\/09031936.99.13359099","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T21:12:37Z","timestamp":1031346757000},"page":"590-596","source":"Crossref","is-referenced-by-count":9,"title":["The effects of surgically treated pulmonary stenosis on lung growth and cardiopulmonary function in children during rest and exercise"],"prefix":"10.1183","volume":"13","author":[{"given":"M","family":"Rosenthal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[1999,3,1]]},"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.99.13359099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:13:36Z","timestamp":1740381216000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.99.13359099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,3,1]]},"published-print":{"date-parts":[[1999,3,1]]}},"alternative-id":["10.1183\/09031936.99.13359099"],"URL":"https:\/\/doi.org\/10.1183\/09031936.99.13359099","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"type":"print","value":"0903-1936"},{"type":"electronic","value":"1399-3003"}],"subject":[],"published":{"date-parts":[[1999,3,1]]}}}