{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:03:40Z","timestamp":1762542220555,"version":"3.40.4"},"reference-count":129,"publisher":"European Respiratory Society (ERS)","issue":"129","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2013,6,17]]},"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Sex prevalence in lung disease suggests that sex-specific hormones may contribute to the pathogenesis and\/or progression of at least some lung diseases, such as lung adenocarcinoma, lymphangioleiomyomatosis (LAM) and benign metastasising leiomyoma (BML). Oestrogen is an important hormone in normal lung development and in the pathogenesis of female predominant pulmonary diseases.<jats:italic>In vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>studies have facilitated our understanding of disease pathogenesis and discovery of potential therapeutic targets. Oestrogen promoted disease progression in cell and animal models of lung adenocarcinoma, LAM and BML. Specifically, oestrogen enhanced tumour growth and metastasis in animal models of these diseases. Furthermore, 17\u03b2-estradiol (E<jats:sub>2<\/jats:sub>), the most abundant form of oestrogen in humans, increased the size and proliferation of cultured cells of lung adenocarcinoma and LAM. Coupled with the known mechanisms of oestrogen metabolism and signalling, these model systems may provide insights into the diverse effects of oestrogen and other hormones on lung diseases. Anti-oestrogen treatments that target key events of oestrogen synthesis or signalling, such as aromatase activity, oestrogen receptors and signalling pathways, may offer additional opportunities for clinical trials.<\/jats:p>","DOI":"10.1183\/09059180.00002813","type":"journal-article","created":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T01:29:40Z","timestamp":1377912580000},"page":"302-311","source":"Crossref","is-referenced-by-count":22,"title":["Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models"],"prefix":"10.1183","volume":"22","author":[{"given":"Bosung","family":"Shim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Pacheco-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Darling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"2025042406002024000_22.129.302.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200409-1298OC"},{"key":"2025042406002024000_22.129.302.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.01.014"},{"key":"2025042406002024000_22.129.302.3","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)03608-L"},{"key":"2025042406002024000_22.129.302.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"2025042406002024000_22.129.302.5","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328356803b"},{"key":"2025042406002024000_22.129.302.6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062836"},{"key":"2025042406002024000_22.129.302.7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001319"},{"key":"2025042406002024000_22.129.302.8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-8-24"},{"key":"2025042406002024000_22.129.302.9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921471"},{"key":"2025042406002024000_22.129.302.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012087"},{"key":"2025042406002024000_22.129.302.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1685OC"},{"key":"2025042406002024000_22.129.302.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1885"},{"key":"2025042406002024000_22.129.302.13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9907008"},{"key":"2025042406002024000_22.129.302.14","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.2.74"},{"key":"2025042406002024000_22.129.302.15","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201249"},{"key":"2025042406002024000_22.129.302.16","unstructured":"Akinbami LJ Liu X . Chronic obstructive pulmonary disease among adults aged 18 and over in the United States, 1998\u20132009. NCHS Data Brief 2011; 1\u20138."},{"key":"2025042406002024000_22.129.302.17","doi-asserted-by":"crossref","unstructured":"Aryal S Diaz-Guzman E Mannino DM . COPD and gender differences: an update. Transl Res 2013 [Epub ahead of print DOI: 10.1016\/j.trsl.2013.04.003].","DOI":"10.1016\/j.trsl.2013.04.003"},{"key":"2025042406002024000_22.129.302.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01987.x"},{"key":"2025042406002024000_22.129.302.19","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0031"},{"key":"2025042406002024000_22.129.302.20","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"2025042406002024000_22.129.302.21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1408CR"},{"key":"2025042406002024000_22.129.302.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.07.007"},{"key":"2025042406002024000_22.129.302.23","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.427"},{"key":"2025042406002024000_22.129.302.24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27987"},{"key":"2025042406002024000_22.129.302.25","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0013"},{"key":"2025042406002024000_22.129.302.26","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1088"},{"key":"2025042406002024000_22.129.302.27","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-15-3-342"},{"key":"2025042406002024000_22.129.302.28","doi-asserted-by":"publisher","DOI":"10.1038\/nature07614"},{"key":"2025042406002024000_22.129.302.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03676.x"},{"key":"2025042406002024000_22.129.302.30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100029200"},{"key":"2025042406002024000_22.129.302.31","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1009"},{"key":"2025042406002024000_22.129.302.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200377097"},{"key":"2025042406002024000_22.129.302.33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207201"},{"key":"2025042406002024000_22.129.302.34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210106200"},{"key":"2025042406002024000_22.129.302.35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8015"},{"key":"2025042406002024000_22.129.302.36","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1+<191::AID-CNCR2820751307>3.0.CO;2-Y"},{"key":"2025042406002024000_22.129.302.37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.2983"},{"key":"2025042406002024000_22.129.302.38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009584"},{"key":"2025042406002024000_22.129.302.39","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.11.869"},{"key":"2025042406002024000_22.129.302.40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04116.x"},{"key":"2025042406002024000_22.129.302.41","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2737"},{"key":"2025042406002024000_22.129.302.42","first-page":"2141","article-title":"Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen","volume":"62","author":"Stabile","year":"2002","journal-title":"Cancer Res"},{"key":"2025042406002024000_22.129.302.43","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2607"},{"key":"2025042406002024000_22.129.302.44","first-page":"4206","article-title":"Steroid receptors in human lung cancer","volume":"45","author":"Beattie","year":"1985","journal-title":"Cancer Res"},{"key":"2025042406002024000_22.129.302.45","first-page":"910","article-title":"Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer","volume":"76","author":"Marquez-Garban","year":"2011","journal-title":"Steroids"},{"key":"2025042406002024000_22.129.302.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00039-9"},{"key":"2025042406002024000_22.129.302.47","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1950"},{"key":"2025042406002024000_22.129.302.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2005.02.017"},{"key":"2025042406002024000_22.129.302.49","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0992"},{"key":"2025042406002024000_22.129.302.50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000471"},{"key":"2025042406002024000_22.129.302.51","first-page":"4693","article-title":"Combined overexpression of EGFR and estrogen receptor alpha correlates with a poor outcome in lung cancer","volume":"25","author":"Kawai","year":"2005","journal-title":"Anticancer Res"},{"key":"2025042406002024000_22.129.302.52","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0498"},{"key":"2025042406002024000_22.129.302.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.07.025"},{"key":"2025042406002024000_22.129.302.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.06.012"},{"key":"2025042406002024000_22.129.302.55","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01118"},{"key":"2025042406002024000_22.129.302.56","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2694"},{"key":"2025042406002024000_22.129.302.57","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5241.1491"},{"key":"2025042406002024000_22.129.302.58","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1872"},{"key":"2025042406002024000_22.129.302.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.11.019"},{"key":"2025042406002024000_22.129.302.60","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-004-0033-2"},{"key":"2025042406002024000_22.129.302.61","first-page":"337","article-title":"Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis","volume":"28","author":"Jarzynka","year":"2006","journal-title":"Int J Oncol"},{"key":"2025042406002024000_22.129.302.62","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0002"},{"key":"2025042406002024000_22.129.302.63","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210493"},{"key":"2025042406002024000_22.129.302.64","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4416"},{"key":"2025042406002024000_22.129.302.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2011.06.002"},{"key":"2025042406002024000_22.129.302.66","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0733"},{"key":"2025042406002024000_22.129.302.67","unstructured":"Moss J Vaughan M , eds. ADP-ribosylating Toxins and G Proteins: Insights into Signal Transduction. Washington, American Society for Microbiology Press, 1990."},{"key":"2025042406002024000_22.129.302.68","unstructured":"Williamson KC Moss J . Mono-ADP-ribosyltransferases and ADP-ribosylarginine hydrolase: a mono-ADP-ribosylation cycle in animal cells. In: Moss J Vaughan M , eds. ADP-ribosylating Toxins and G Proteins: Insights into Signal Transduction. Washington, American Society for Microbiology Press, 1990; pp. 493\u2013510.."},{"key":"2025042406002024000_22.129.302.69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23617"},{"key":"2025042406002024000_22.129.302.70","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.19.1.485"},{"key":"2025042406002024000_22.129.302.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74388-9"},{"key":"2025042406002024000_22.129.302.72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510290200"},{"key":"2025042406002024000_22.129.302.73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607911103"},{"key":"2025042406002024000_22.129.302.74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.237636"},{"key":"2025042406002024000_22.129.302.75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5603"},{"key":"2025042406002024000_22.129.302.76","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(19)50043-6"},{"key":"2025042406002024000_22.129.302.77","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842216"},{"key":"2025042406002024000_22.129.302.78","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.1041"},{"key":"2025042406002024000_22.129.302.79","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199909000-00004"},{"key":"2025042406002024000_22.129.302.80","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.12.1052"},{"key":"2025042406002024000_22.129.302.81","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0024"},{"key":"2025042406002024000_22.129.302.82","doi-asserted-by":"publisher","DOI":"10.4065\/75.6.591"},{"key":"2025042406002024000_22.129.302.83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055323"},{"key":"2025042406002024000_22.129.302.84","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"2025042406002024000_22.129.302.85","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202678200"},{"key":"2025042406002024000_22.129.302.86","doi-asserted-by":"publisher","DOI":"10.1101\/gad.351605"},{"key":"2025042406002024000_22.129.302.87","doi-asserted-by":"publisher","DOI":"10.1101\/gad.995802"},{"key":"2025042406002024000_22.129.302.88","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1974"},{"key":"2025042406002024000_22.129.302.89","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000207"},{"key":"2025042406002024000_22.129.302.90","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-0960-BMLOTU"},{"key":"2025042406002024000_22.129.302.91","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58709"},{"key":"2025042406002024000_22.129.302.92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407971101"},{"key":"2025042406002024000_22.129.302.93","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0031"},{"key":"2025042406002024000_22.129.302.94","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318240090e"},{"key":"2025042406002024000_22.129.302.95","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107233050406"},{"key":"2025042406002024000_22.129.302.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.147"},{"key":"2025042406002024000_22.129.302.97","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.25"},{"key":"2025042406002024000_22.129.302.98","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800504"},{"key":"2025042406002024000_22.129.302.99","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(96)80224-X"},{"key":"2025042406002024000_22.129.302.100","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2011.43.2.131"},{"key":"2025042406002024000_22.129.302.101","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34893-2"},{"key":"2025042406002024000_22.129.302.102","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1737OC"},{"key":"2025042406002024000_22.129.302.103","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.11.4996"},{"key":"2025042406002024000_22.129.302.104","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00204.2003"},{"key":"2025042406002024000_22.129.302.105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810790106"},{"key":"2025042406002024000_22.129.302.106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03991.x"},{"key":"2025042406002024000_22.129.302.107","doi-asserted-by":"publisher","DOI":"10.2307\/3454314"},{"key":"2025042406002024000_22.129.302.108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038589"},{"key":"2025042406002024000_22.129.302.109","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0123"},{"key":"2025042406002024000_22.129.302.110","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205962"},{"key":"2025042406002024000_22.129.302.111","doi-asserted-by":"publisher","DOI":"10.1038\/35010550"},{"key":"2025042406002024000_22.129.302.112","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1283"},{"key":"2025042406002024000_22.129.302.113","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0267-RFAOMM"},{"key":"2025042406002024000_22.129.302.114","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0018"},{"key":"2025042406002024000_22.129.302.115","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00009311"},{"key":"2025042406002024000_22.129.302.116","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00313.2007"},{"key":"2025042406002024000_22.129.302.117","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62470-4"},{"key":"2025042406002024000_22.129.302.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2009.06.002"},{"key":"2025042406002024000_22.129.302.119","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.16.1855"},{"key":"2025042406002024000_22.129.302.120","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0340OC"},{"key":"2025042406002024000_22.129.302.121","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00389.2009"},{"key":"2025042406002024000_22.129.302.122","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0533"},{"key":"2025042406002024000_22.129.302.123","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950415)75:8<2132::AID-CNCR2820750816>3.0.CO;2-U"},{"key":"2025042406002024000_22.129.302.124","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1879"},{"key":"2025042406002024000_22.129.302.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2009.06.010"},{"key":"2025042406002024000_22.129.302.126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063564"},{"key":"2025042406002024000_22.129.302.127","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.03.017"},{"key":"2025042406002024000_22.129.302.128","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3840"},{"key":"2025042406002024000_22.129.302.129","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1165\/rcmb.2012-0476OC","article-title":"Faslodex inhibits estradiol-induced ECM dynamics and lung metastasis in a model of LAM","volume":"49","author":"Li","year":"2013","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["European Respiratory Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09059180.00002813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:00:36Z","timestamp":1745499636000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09059180.00002813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,30]]},"references-count":129,"journal-issue":{"issue":"129","published-online":{"date-parts":[[2013,8,30]]},"published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1183\/09059180.00002813"],"URL":"https:\/\/doi.org\/10.1183\/09059180.00002813","relation":{},"ISSN":["0905-9180","1600-0617"],"issn-type":[{"type":"print","value":"0905-9180"},{"type":"electronic","value":"1600-0617"}],"subject":[],"published":{"date-parts":[[2013,8,30]]}}}