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Mucoactive agents have been the medication of choice for the treatment of respiratory diseases in which mucus hypersecretion is a clinical complication. The main purpose of mucoactive drugs is to increase the ability to expectorate sputum and\/or decrease mucus hypersecretion. Many mucoactive drugs are currently available and can be classified according to their putative mechanism of action. Mucoactive medications include expectorants, mucoregulators, mucolytics and mucokinetics. By developing our understanding of the specific effects of mucoactive agents, we may result in improved therapeutic use of these drugs. The present review provides a summary of the most clinically relevant mucoactive drugs in addition to their potential mechanism of action.<\/jats:p>","DOI":"10.1183\/09059180.00003510","type":"journal-article","created":{"date-parts":[[2010,5,31]],"date-time":"2010-05-31T20:50:58Z","timestamp":1275339058000},"page":"127-133","source":"Crossref","is-referenced-by-count":145,"title":["Mucoactive drugs"],"prefix":"10.1183","volume":"19","author":[{"given":"R.","family":"Balsamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lanata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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