{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:42:13Z","timestamp":1759963333146,"version":"3.40.4"},"reference-count":65,"publisher":"European Respiratory Society (ERS)","issue":"130","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2013,10,14]]},"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Pulmonary arterial hypertension (PAH) is a progressive vasculopathy that is advanced by the time symptoms develop. As symptoms are nonspecific and the condition uncommon, continued progression toward end-stage disease occurs for an average of 2 years between symptom onset and diagnosis. There is need for earlier diagnosis and treatment, as most patients are severely symptomatic when diagnosed and their mortality is high despite therapy. Screening can help; however, it is not straightforward due to the diversity of patient profiles and lack of sufficiently accurate tools. Echocardiography, currently the best available screening tool, lacks both sensitivity and specificity. The low prevalence of PAH renders many screening tools unfit for purpose. However, this may be overcome, in some instances, by using enrichment tools to preselect screening populations. The majority of data are available for systemic sclerosis. A recent study has demonstrated how lung function can be used to enrich PAH prevalence in a systemic sclerosis population. A screening bundle then selects patients for right heart catheterisation with improved rates of sensitivity compared to current guidelines.<\/jats:p>","DOI":"10.1183\/09059180.00006013","type":"journal-article","created":{"date-parts":[[2013,11,30]],"date-time":"2013-11-30T01:42:15Z","timestamp":1385775735000},"page":"515-525","source":"Crossref","is-referenced-by-count":25,"title":["Screening patients with scleroderma for pulmonary arterial hypertension and implications for other at-risk populations"],"prefix":"10.1183","volume":"22","author":[{"given":"Johannes P.","family":"Schwaiger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gerry Coghlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2013,11,29]]},"reference":[{"key":"2025042406003136000_22.130.515.1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.168.1.8976910"},{"key":"2025042406003136000_22.130.515.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206809"},{"key":"2025042406003136000_22.130.515.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911818"},{"key":"2025042406003136000_22.130.515.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60919-8"},{"key":"2025042406003136000_22.130.515.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00078411"},{"key":"2025042406003136000_22.130.515.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200806-953OC"},{"key":"2025042406003136000_22.130.515.7","doi-asserted-by":"crossref","unstructured":"Launay D Sitbon O Hachulla E . Survival in systemic sclerosis-associated pulmonary arterial hypertension in the modern management era. Ann Rheum Dis 2012 [in press DOI: 10.1136\/annrheumdis-2012-202489].","DOI":"10.1136\/annrheumdis-2012-202489"},{"key":"2025042406003136000_22.130.515.8","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100245"},{"key":"2025042406003136000_22.130.515.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1088"},{"key":"2025042406003136000_22.130.515.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"2025042406003136000_22.130.515.11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken488"},{"key":"2025042406003136000_22.130.515.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.30541"},{"key":"2025042406003136000_22.130.515.13","doi-asserted-by":"crossref","unstructured":"Chung L Domsic RT Lingala B . Survival and predictors of mortality in systemic sclerosis associated pulmonary arterial hypertension: outcomes from the PHAROS registry. Arthritis Care Res (Hoboken) 2013 [in press DOI: 10.1002\/acr.22121].","DOI":"10.1002\/acr.22121"},{"key":"2025042406003136000_22.130.515.14","doi-asserted-by":"crossref","unstructured":"Coghlan JG Denton CP Gr\u00fcnig E . Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2013 [in press DOI: 10.1136\/annrheumdis-2013-203301].","DOI":"10.1136\/annrheumdis-2013-eular.241"},{"key":"2025042406003136000_22.130.515.15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"2025042406003136000_22.130.515.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"2025042406003136000_22.130.515.17","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090661"},{"key":"2025042406003136000_22.130.515.18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.2.239"},{"key":"2025042406003136000_22.130.515.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1691OC"},{"key":"2025042406003136000_22.130.515.20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh067"},{"key":"2025042406003136000_22.130.515.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005565"},{"key":"2025042406003136000_22.130.515.22","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283579653"},{"key":"2025042406003136000_22.130.515.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-547OC"},{"key":"2025042406003136000_22.130.515.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.07.016"},{"key":"2025042406003136000_22.130.515.25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.091421"},{"key":"2025042406003136000_22.130.515.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"2025042406003136000_22.130.515.27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057760"},{"key":"2025042406003136000_22.130.515.28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.2.279"},{"key":"2025042406003136000_22.130.515.29","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00145608"},{"key":"2025042406003136000_22.130.515.30","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2324"},{"key":"2025042406003136000_22.130.515.31","doi-asserted-by":"publisher","DOI":"10.1002\/art.38043"},{"key":"2025042406003136000_22.130.515.32","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.203471"},{"key":"2025042406003136000_22.130.515.33","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"2025042406003136000_22.130.515.34","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.2.131"},{"key":"2025042406003136000_22.130.515.35","doi-asserted-by":"publisher","DOI":"10.1002\/art.34501"},{"key":"2025042406003136000_22.130.515.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.11.022"},{"key":"2025042406003136000_22.130.515.37","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081277"},{"key":"2025042406003136000_22.130.515.38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-132-6-200003210-00002","article-title":"Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial","volume":"132","author":"Badesch","year":"2000","journal-title":"Ann Intern Med"},{"key":"2025042406003136000_22.130.515.39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213917"},{"key":"2025042406003136000_22.130.515.40","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0260"},{"key":"2025042406003136000_22.130.515.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.03.005"},{"key":"2025042406003136000_22.130.515.42","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi891"},{"key":"2025042406003136000_22.130.515.43","doi-asserted-by":"publisher","DOI":"10.1002\/art.23187"},{"key":"2025042406003136000_22.130.515.44","doi-asserted-by":"publisher","DOI":"10.1186\/ar3876"},{"key":"2025042406003136000_22.130.515.45","doi-asserted-by":"publisher","DOI":"10.1002\/art.30432"},{"key":"2025042406003136000_22.130.515.46","doi-asserted-by":"publisher","DOI":"10.1002\/art.30535"},{"key":"2025042406003136000_22.130.515.47","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130400"},{"key":"2025042406003136000_22.130.515.48","doi-asserted-by":"publisher","DOI":"10.1002\/art.30077"},{"key":"2025042406003136000_22.130.515.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.08.004"},{"key":"2025042406003136000_22.130.515.50","doi-asserted-by":"crossref","unstructured":"Khanna D Gladue H Channick R . Recommendations for screening and detection of connective-tissue disease associated pulmonary arterial hypertension. Arthritis Rheum 2013 [in press DOI: 10.1002\/art.38172].","DOI":"10.1002\/art.38172"},{"key":"2025042406003136000_22.130.515.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.028"},{"key":"2025042406003136000_22.130.515.52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0886OC"},{"key":"2025042406003136000_22.130.515.53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.800938"},{"key":"2025042406003136000_22.130.515.54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.015008"},{"key":"2025042406003136000_22.130.515.55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032274"},{"key":"2025042406003136000_22.130.515.56","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.172"},{"key":"2025042406003136000_22.130.515.57","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00009111"},{"key":"2025042406003136000_22.130.515.58","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.039438"},{"key":"2025042406003136000_22.130.515.59","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0160"},{"key":"2025042406003136000_22.130.515.60","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21431"},{"key":"2025042406003136000_22.130.515.61","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.5.1268"},{"key":"2025042406003136000_22.130.515.62","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-541OC"},{"key":"2025042406003136000_22.130.515.63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.630715"},{"key":"2025042406003136000_22.130.515.64","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.883876"},{"key":"2025042406003136000_22.130.515.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.10.014"}],"container-title":["European Respiratory Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09059180.00006013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:00:57Z","timestamp":1745499657000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09059180.00006013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":65,"journal-issue":{"issue":"130","published-online":{"date-parts":[[2013,11,29]]},"published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1183\/09059180.00006013"],"URL":"https:\/\/doi.org\/10.1183\/09059180.00006013","relation":{},"ISSN":["0905-9180","1600-0617"],"issn-type":[{"type":"print","value":"0905-9180"},{"type":"electronic","value":"1600-0617"}],"subject":[],"published":{"date-parts":[[2013,11,29]]}}}