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Driven by the hypothesis that \u201cleft\u201d and right heart failure might share important underlying pathophysiological mechanisms, we evaluated the clinical potential of left heart failure (LHF) therapies for PAH, based on currently available literature.<\/jats:p><jats:p>As in LHF, the sympathetic nervous system and the renin\u2013angiotension\u2013aldosterone system are highly activated in PAH. From LHF we know that intervening in this process,<jats:italic>e.g.<\/jats:italic>by angiotensin-converting enzyme inhibition or \u03b2-blockade, is beneficial in the long run. Therefore, these medications could be also beneficial in PAH. Furthermore, the incidence of sudden cardiac death in PAH could be reduced by implantable cardioverter-defibrillators. Finally, pilot studies have demonstrated that interventricular dyssynchrony, present at end-stage PAH, responded favourably to cardiac resynchronisation therapy as well.<\/jats:p><jats:p>In conclusion, therapies for LHF might be relevant for PAH. However, before they can be implemented in PAH management, safety and efficacy should be evaluated first in well-designed clinical trials.<\/jats:p>","DOI":"10.1183\/09059180.00007109","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T01:12:57Z","timestamp":1267405977000},"page":"72-82","source":"Crossref","is-referenced-by-count":110,"title":["Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart"],"prefix":"10.1183","volume":"19","author":[{"given":"M. L.","family":"Handoko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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