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Thymomas may be associated with autoimmune disorders.<\/jats:p>\n                  <jats:p>The management of thymic epithelial tumours is a paradigm of co-operation between clinicians, surgeons and pathologists, from establishing the diagnosis to organising the multimodal therapeutic strategy. Surgery is the mainstay of the curative-intent treatment, as complete resection represents the most significantly favourable prognostic factor on overall survival. In case of invasion of intra-thoracic structures and\/or dissemination to the pleura and the pericardium, precluding complete resection to be achieved, primary chemotherapy has been used to reduce the tumour burden, possibly allowing subsequent surgery and\/or radiotherapy.<\/jats:p>\n                  <jats:p>Novel strategies are needed, especially for refractory, recurrent tumours and thymic carcinomas, which carry a poor prognosis. Personalised approaches are currently being developed, as potentially \u201cdruggable\u201d molecular targets are emerging from recent integrated genomic analyses. Along with the large variety of questions relative to the treatment strategy, thymic epithelial tumours represent a model of therapeutic implementation and achievement in orphan thoracic oncology, showing how the advent of new results induces new questions, as well as diversifies further clinical research directions and international collaborative initiatives.<\/jats:p>","DOI":"10.1183\/09059180.00007312","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T15:45:33Z","timestamp":1362152733000},"page":"75-87","source":"Crossref","is-referenced-by-count":33,"title":["Thymic epithelial tumours: from basic principles to individualised treatment strategies"],"prefix":"10.1183","volume":"22","author":[{"given":"Nicolas","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"2025042405151760000_22.127.75.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.004"},{"key":"2025042405151760000_22.127.75.2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818e105c"},{"key":"2025042405151760000_22.127.75.3","unstructured":"Travis WB Brambilla A Muller-Hermelinck HK . 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