{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:31:31Z","timestamp":1793035891083,"version":"4.5.0"},"reference-count":64,"publisher":"European Respiratory Society (ERS)","issue":"134","content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir Rev"],"accepted":{"date-parts":[[2014,9,30]]},"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH, the right ventricle tends to remain adapted to afterload with increased contractility and little or no increase in right heart chamber dimensions. However, less than optimal right ventricular (RV)\u2013arterial coupling may already cause a decreased aerobic exercise capacity by limiting maximum cardiac output. In more advanced stages, RV systolic function cannot remain matched to afterload and dilatation of the right heart chamber progressively develops. In addition, diastolic dysfunction occurs due to myocardial fibrosis and sarcomeric stiffening. All these changes lead to limitation of RV flow output, increased right-sided filling pressures and under-filling of the left ventricle, with eventual decrease in systemic blood pressure and altered systolic ventricular interaction. These pathophysiological changes account for exertional dyspnoea and systemic venous congestion typical of PAH. Complete evaluation of RV failure requires echocardiographic or magnetic resonance imaging, and right heart catheterisation measurements. Treatment of RV failure in PAH relies on: decreasing afterload with drugs targeting pulmonary circulation; fluid management to optimise ventricular diastolic interactions; and inotropic interventions to reverse cardiogenic shock. To date, there has been no report of the efficacy of drug treatments that specifically target the right ventricle.<\/jats:p>","DOI":"10.1183\/09059180.00007414","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T05:40:23Z","timestamp":1417412423000},"page":"476-487","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":261,"title":["The right ventricle in pulmonary arterial hypertension"],"prefix":"10.1183","volume":"23","author":[{"given":"Robert","family":"Naeije","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Manes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"issue":"Suppl. 25","key":"2024102403130127000_23.134.476.1","first-page":"D45","article-title":"Definitions and diagnosis of pulmonary hypertension","volume":"62","author":"Hoeper","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2024102403130127000_23.134.476.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.027"},{"key":"2024102403130127000_23.134.476.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653576"},{"key":"2024102403130127000_23.134.476.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.2.4.326"},{"key":"2024102403130127000_23.134.476.5","unstructured":"Sagawa K Maughan L Suga H , eds, et al. Cardiac Contraction and the Pressure-Volume Relationship. Oxford, Oxford University Press, 1988."},{"key":"2024102403130127000_23.134.476.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.8.5.1077"},{"key":"2024102403130127000_23.134.476.7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1912.sp001553"},{"key":"2024102403130127000_23.134.476.8","doi-asserted-by":"crossref","unstructured":"Taquini AC Fermoso JD Aramendia P . Behaviour of the right ventricle following acute constriction of the pulmonary artery. Circ Res;1960: 315\u2013318.","DOI":"10.1161\/01.RES.8.2.315"},{"key":"2024102403130127000_23.134.476.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00160712"},{"key":"2024102403130127000_23.134.476.10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1086\/677354","article-title":"Biomechanics of the right ventricle","volume":"4","author":"Naeije","year":"2014","journal-title":"Pulm Circ"},{"key":"2024102403130127000_23.134.476.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.32.3.314"},{"key":"2024102403130127000_23.134.476.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.3.309"},{"key":"2024102403130127000_23.134.476.13","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.1.45"},{"key":"2024102403130127000_23.134.476.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000008"},{"key":"2024102403130127000_23.134.476.15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1109\/TBME.1980.326737","article-title":"Estimation of the hydromotive source pressure from ejecting beats of the left ventricle","volume":"57","author":"Sunagawa","year":"1980","journal-title":"IEEE Trans Biomed Eng"},{"key":"2024102403130127000_23.134.476.16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01023.2002"},{"key":"2024102403130127000_23.134.476.17","doi-asserted-by":"crossref","unstructured":"Vanderpool RR Pinsky MR Naeije R et al . RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart 2014 [In press DOI: 10.1136\/heartjnl-2014-306142].","DOI":"10.1136\/heartjnl-2014-306142"},{"key":"2024102403130127000_23.134.476.18","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.12.864"},{"key":"2024102403130127000_23.134.476.19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143138.02493.DD"},{"key":"2024102403130127000_23.134.476.20","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951105001848"},{"key":"2024102403130127000_23.134.476.21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/japplphysiol.01123.2013","article-title":"Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery","volume":"116","author":"McCabe","year":"2013","journal-title":"J Appl Physiol"},{"key":"2024102403130127000_23.134.476.22","doi-asserted-by":"publisher","DOI":"10.3109\/13813455909072295"},{"key":"2024102403130127000_23.134.476.23","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0492"},{"key":"2024102403130127000_23.134.476.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046612"},{"key":"2024102403130127000_23.134.476.25","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.109957"},{"key":"2024102403130127000_23.134.476.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01496-6"},{"key":"2024102403130127000_23.134.476.27","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181de8bd3"},{"key":"2024102403130127000_23.134.476.28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069470"},{"key":"2024102403130127000_23.134.476.29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0662CI"},{"key":"2024102403130127000_23.134.476.30","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2659"},{"key":"2024102403130127000_23.134.476.31","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000120052.77953.07"},{"key":"2024102403130127000_23.134.476.32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.964494"},{"key":"2024102403130127000_23.134.476.33","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0335OC"},{"key":"2024102403130127000_23.134.476.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00320-4"},{"key":"2024102403130127000_23.134.476.35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655266"},{"key":"2024102403130127000_23.134.476.36","first-page":"1430","article-title":"Effects of nitric oxide and prostacyclin in an over-circulation model of pulmonary hypertension","volume":"125","author":"Wauthy","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024102403130127000_23.134.476.37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1615OC"},{"key":"2024102403130127000_23.134.476.38","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0831-8"},{"key":"2024102403130127000_23.134.476.39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00332.2006"},{"key":"2024102403130127000_23.134.476.40","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs094"},{"key":"2024102403130127000_23.134.476.41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053443.27512.33"},{"key":"2024102403130127000_23.134.476.42","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300462"},{"key":"2024102403130127000_23.134.476.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.022"},{"key":"2024102403130127000_23.134.476.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.068"},{"key":"2024102403130127000_23.134.476.45","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90261-6"},{"key":"2024102403130127000_23.134.476.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.088"},{"key":"2024102403130127000_23.134.476.47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.5.620"},{"key":"2024102403130127000_23.134.476.48","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00135407"},{"key":"2024102403130127000_23.134.476.49","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3283437485"},{"key":"2024102403130127000_23.134.476.50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00286.2006"},{"key":"2024102403130127000_23.134.476.51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001573"},{"key":"2024102403130127000_23.134.476.52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200910-1643OC"},{"key":"2024102403130127000_23.134.476.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.009"},{"key":"2024102403130127000_23.134.476.54","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.83446"},{"key":"2024102403130127000_23.134.476.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.11.011"},{"key":"2024102403130127000_23.134.476.56","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013773.67850.BA"},{"key":"2024102403130127000_23.134.476.57","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001873"},{"key":"2024102403130127000_23.134.476.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(98)80049-2"},{"key":"2024102403130127000_23.134.476.59","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90990-T"},{"key":"2024102403130127000_23.134.476.60","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.546"},{"key":"2024102403130127000_23.134.476.61","first-page":"H1514","article-title":"Significant left ventricular contribution to right ventricular systolic function","volume":"261","author":"Damiano","year":"1991","journal-title":"Am J Physiol"},{"key":"2024102403130127000_23.134.476.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.041"},{"key":"2024102403130127000_23.134.476.63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650994"},{"key":"2024102403130127000_23.134.476.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.084"}],"container-title":["European Respiratory Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09059180.00007414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T23:57:22Z","timestamp":1740355042000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09059180.00007414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":64,"journal-issue":{"issue":"134","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1183\/09059180.00007414"],"URL":"https:\/\/doi.org\/10.1183\/09059180.00007414","relation":{},"ISSN":["0905-9180","1600-0617"],"issn-type":[{"value":"0905-9180","type":"print"},{"value":"1600-0617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}