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Many tools, such as symptoms, functional classification, exercise capacity, haemodynamic measures, findings on cardiac imaging and levels of biomarkers, have shown to be prognostic for survival both at diagnosis and during treatment. However, attempts to define goal thresholds have produced a variety of results.<\/jats:p><jats:p>Several groups have developed risk calculators to estimate individual patients' mortality risk, but the accuracy of these tools across different patient populations remains unknown. What is clear is the importance of regularly assessing a range of parameters and then tailoring treatment goals to each patient. In addition, the use of a multidisciplinary team approach is crucial in order to support patients through all aspects of managing their condition.<\/jats:p><jats:p>There is still an urgent need for prospective collaborative initiatives to assess novel goals and improve treatment strategies that would allow physicians to personalise and optimise clinical management for their patients with PAH.<\/jats:p>","DOI":"10.1183\/09059180.00009011","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T06:53:16Z","timestamp":1330498396000},"page":"40-47","source":"Crossref","is-referenced-by-count":35,"title":["How to detect disease progression in pulmonary arterial hypertension"],"prefix":"10.1183","volume":"21","author":[{"given":"J-L.","family":"Vachi\u00e9ry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Yerly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Huez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"2025042404453479000_21.123.40.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp022"},{"key":"2025042404453479000_21.123.40.2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-12"},{"key":"2025042404453479000_21.123.40.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898122"},{"key":"2025042404453479000_21.123.40.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.911818"},{"key":"2025042404453479000_21.123.40.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029100.82385.58"},{"key":"2025042404453479000_21.123.40.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02012-0"},{"key":"2025042404453479000_21.123.40.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60919-8"},{"key":"2025042404453479000_21.123.40.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742510"},{"key":"2025042404453479000_21.123.40.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012212"},{"key":"2025042404453479000_21.123.40.10","unstructured":"Badesch DB Barst RJ Galie N . 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