{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:07:56Z","timestamp":1772165276099,"version":"3.50.1"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,4,5]]},"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Familial clustering of pleural mesothelioma was reported previously, but none of the reports quantified the familial risk of mesothelioma or the association with other cancers. The contributions of shared environmental or genetic factors to the aggregation of mesothelioma were unknown.<\/jats:p>\n                  <jats:p>We used a number of Swedish registers, including the Swedish Multigeneration Register and the Swedish Cancer Register, to examine the familial risk of mesothelioma in offspring. Standardised incidence ratios (SIRs) were used to calculate the risk. Age standardised incidence rates of mesothelioma were calculated from the Swedish Cancer Registry.<\/jats:p>\n                  <jats:p>The incidence of mesothelioma reached its peak rate in 2000 and decreased thereafter. Risk of mesothelioma was significantly increased when parents or siblings were diagnosed with mesothelioma, with SIRs of 3.88 (95% CI 1.01\u201310.04) and 12.37 (95% CI 5.89\u201322.84), respectively. Mesothelioma was associated with kidney (SIR 2.13, 95% CI 1.16\u20133.59) and bladder cancers (SIR 2.09, 95% CI 1.32\u20133.14) in siblings. No association was found between spouses.<\/jats:p>\n                  <jats:p>Family history of mesothelioma, including both parental and sibling history, is an important risk factor for mesothelioma. Shared genetic factors may contribute to the observed familial clustering of mesothelioma, but the contribution of shared environmental factors could not be neglected. The association with kidney and bladder cancers calls for further study to explore the underlying mechanisms.<\/jats:p>","DOI":"10.1183\/13993003.00091-2016","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T22:11:50Z","timestamp":1463091110000},"page":"873-879","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Incidence and familial risk of pleural mesothelioma in Sweden: a national cohort study"],"prefix":"10.1183","volume":"48","author":[{"given":"Jianguang","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"2024102100024428000_48.3.873.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"2024102100024428000_48.3.873.2","doi-asserted-by":"publisher","DOI":"10.1136\/oem.56.2.110"},{"key":"2024102100024428000_48.3.873.3","doi-asserted-by":"publisher","DOI":"10.1136\/oem.51.4.244"},{"key":"2024102100024428000_48.3.873.4","first-page":"48","article-title":"Occupational exposure to asbestos as evaluated from work histories and analysis of lung tissues from patients with mesothelioma","volume":"48","author":"Tuomi","year":"1991","journal-title":"Br J Ind Med"},{"key":"2024102100024428000_48.3.873.5","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203744"},{"key":"2024102100024428000_48.3.873.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604879"},{"key":"2024102100024428000_48.3.873.7","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132014000500018"},{"key":"2024102100024428000_48.3.873.8","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101957"},{"key":"2024102100024428000_48.3.873.9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/030089161209800205","article-title":"Asbestos and SV40 in malignant pleural mesothelioma from a hyperendemic area of north-eastern Italy","volume":"98","author":"Comar","year":"2012","journal-title":"Tumori"},{"key":"2024102100024428000_48.3.873.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213238109"},{"key":"2024102100024428000_48.3.873.11","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv097"},{"key":"2024102100024428000_48.3.873.12","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0140-6736(78)90911-X","article-title":"Non-occupational exposure to asbestos and malignant mesothelioma in females","volume":"1","author":"Vianna","year":"1978","journal-title":"Lancet"},{"key":"2024102100024428000_48.3.873.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04013-7"},{"key":"2024102100024428000_48.3.873.14","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27758"},{"key":"2024102100024428000_48.3.873.15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt135"},{"key":"2024102100024428000_48.3.873.16","first-page":"705","article-title":"Mesotheliomes familiaux: une composante genetique associee aux risques environnementaux? 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