{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:32:45Z","timestamp":1790256765028,"version":"4.1.0"},"reference-count":55,"publisher":"European Respiratory Society (ERS)","issue":"5","funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1-RR-025005"],"award-info":[{"award-number":["UL1-RR-025005"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL077612"],"award-info":[{"award-number":["R01 HL077612"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL103676"],"award-info":[{"award-number":["R01 HL103676"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL114626"],"award-info":[{"award-number":["R01 HL114626"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL083091"],"award-info":[{"award-number":["R01-HL083091"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RC1-100543"],"award-info":[{"award-number":["RC1-100543"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL105323"],"award-info":[{"award-number":["T32 HL105323"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003284","name":"Pulmonary Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,5,7]]},"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.<\/jats:p>\n                  <jats:p>We measured high attenuation areas (HAA; percentage of lung voxels between \u2212600 and \u2212250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.<\/jats:p>\n                  <jats:p>HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3\u201311.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8\u201313.0), lower forced vital capacity (FVC) (mean adjusted difference \u221282\u2005mL, 95% CI \u2212119\u2013\u221244), lower 6-min walk distance (mean adjusted difference \u221240\u2005m, 95% CI \u22121\u2013\u221280), higher odds of interstitial lung abnormalities at 9.5\u2005years (adjusted OR 1.95, 95% CI 1.43\u20132.65), and higher all cause-mortality rate over 12.2\u2005years (HR 1.58, 95% CI 1.39\u20131.79).<\/jats:p>\n                  <jats:p>High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.<\/jats:p>","DOI":"10.1183\/13993003.00129-2016","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T22:18:37Z","timestamp":1469744317000},"page":"1442-1452","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":150,"title":["High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study"],"prefix":"10.1183","volume":"48","author":[{"given":"Anna J.","family":"Podolanczuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Oelsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Graham","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary F.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.M.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Basner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Enright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette R.","family":"Gochuico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hinckley Stukovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hrudaya Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John D.","family":"Newell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rabinowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Raghu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Sell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jered","family":"Sieren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil K.","family":"Sonavane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jubal R.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleen","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Kawut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"2024102100082498000_48.5.1442.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-0997ED"},{"key":"2024102100082498000_48.5.1442.2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31821a9d8e"},{"key":"2024102100082498000_48.5.1442.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-254OC"},{"key":"2024102100082498000_48.5.1442.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1420PP"},{"key":"2024102100082498000_48.5.1442.5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.201406-1162OC","article-title":"Extensive phenotyping of individuals at-risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease","volume":"191","author":"Kropski","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102100082498000_48.5.1442.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007285"},{"key":"2024102100082498000_48.5.1442.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1618OC"},{"key":"2024102100082498000_48.5.1442.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1216076"},{"key":"2024102100082498000_48.5.1442.9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0518"},{"key":"2024102100082498000_48.5.1442.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1966OC"},{"key":"2024102100082498000_48.5.1442.11","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0124-x"},{"key":"2024102100082498000_48.5.1442.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"},{"key":"2024102100082498000_48.5.1442.13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.2.466"},{"key":"2024102100082498000_48.5.1442.14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9901117"},{"key":"2024102100082498000_48.5.1442.15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2107134"},{"key":"2024102100082498000_48.5.1442.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00081102"},{"key":"2024102100082498000_48.5.1442.17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2209"},{"key":"2024102100082498000_48.5.1442.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201101-0058OC"},{"key":"2024102100082498000_48.5.1442.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050093"},{"key":"2024102100082498000_48.5.1442.20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092134099"},{"key":"2024102100082498000_48.5.1442.21","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"2024102100082498000_48.5.1442.22","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341040439"},{"key":"2024102100082498000_48.5.1442.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2008.12.024"},{"key":"2024102100082498000_48.5.1442.24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633722"},{"key":"2024102100082498000_48.5.1442.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024102100082498000_48.5.1442.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0919"},{"key":"2024102100082498000_48.5.1442.27","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2024102100082498000_48.5.1442.28","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204992"},{"key":"2024102100082498000_48.5.1442.29","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201310-364OC"},{"key":"2024102100082498000_48.5.1442.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2009.07.016"},{"key":"2024102100082498000_48.5.1442.31","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2570"},{"key":"2024102100082498000_48.5.1442.32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12568"},{"key":"2024102100082498000_48.5.1442.33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64931"},{"key":"2024102100082498000_48.5.1442.34","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-63"},{"key":"2024102100082498000_48.5.1442.35","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.15.15"},{"key":"2024102100082498000_48.5.1442.36","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0075"},{"key":"2024102100082498000_48.5.1442.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03203.x"},{"key":"2024102100082498000_48.5.1442.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.005"},{"key":"2024102100082498000_48.5.1442.39","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0068-7"},{"key":"2024102100082498000_48.5.1442.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.02.006"},{"key":"2024102100082498000_48.5.1442.41","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000029781.31325.66"},{"key":"2024102100082498000_48.5.1442.42","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0083OC"},{"key":"2024102100082498000_48.5.1442.43","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0568-z"},{"key":"2024102100082498000_48.5.1442.44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1516"},{"key":"2024102100082498000_48.5.1442.45","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31820ccf18"},{"key":"2024102100082498000_48.5.1442.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.01.008"},{"key":"2024102100082498000_48.5.1442.47","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000184"},{"key":"2024102100082498000_48.5.1442.48","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00071812"},{"key":"2024102100082498000_48.5.1442.49","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-015-0214-6"},{"key":"2024102100082498000_48.5.1442.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3946-2"},{"key":"2024102100082498000_48.5.1442.51","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000127"},{"key":"2024102100082498000_48.5.1442.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2006.04.017"},{"key":"2024102100082498000_48.5.1442.53","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0222ED"},{"key":"2024102100082498000_48.5.1442.54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808836"},{"key":"2024102100082498000_48.5.1442.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60860-1"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00129-2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:35:36Z","timestamp":1740360936000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00129-2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,28]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,10,31]]},"published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1183\/13993003.00129-2016"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00129-2016","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,28]]}}}