{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:36:57Z","timestamp":1791049017875,"version":"4.1.0"},"reference-count":52,"publisher":"European Respiratory Society (ERS)","issue":"2","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1090198"],"award-info":[{"award-number":["APP1090198"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,5,26]]},"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>There is uncertainty regarding whether patients with cancer should be screened for latent tuberculosis infection (LTBI). We performed a systematic review and meta-analysis to estimate the relative incidence of tuberculosis (TB) in cancer.<\/jats:p><jats:p>We searched MEDLINE and Embase for studies published before December 21, 2016. We included studies that evaluated the incidence of TB in patients with solid cancers and haematological malignancies relative to a reference group (study control or general population). A pooled estimate of the incidence rate ratio (IRR) was obtained using standard meta-analysis methods.<\/jats:p><jats:p>The search strategy identified 13 unique studies including 921\u2005464 patients with cancer. The IRR of TB for adult patients with cancer was 2.61 (95% CI 2.12\u20133.22;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=91%). In haematological cancers, the IRR was 3.53 (95% CI 1.63\u20137.64;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=96%); and in solid cancers in adults, it was 2.25 (95% CI 1.96\u20132.58;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=91%). The highest IRR was found in children with haematological malignancies or solid cancers (IRR 16.82, 95% CI 8.81\u201332.12;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=79%).<\/jats:p><jats:p>Considering the limited duration of maximum immunosuppression in cancer and reduced cumulative lifetime risk of TB because of reduced life expectancy, children, but not adults, appear to be at a sufficient level of risk to warrant systematic screening for LTBI.<\/jats:p>","DOI":"10.1183\/13993003.00157-2017","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:10:29Z","timestamp":1503619829000},"page":"1700157","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":113,"title":["Risk of tuberculosis in patients with solid\u00a0cancers and haematological malignancies: a systematic review and\u00a0meta-analysis"],"prefix":"10.1183","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-0189","authenticated-orcid":false,"given":"Claudia C.","family":"Dobler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"2024101904193438000_50.2.1700157.1","unstructured":"World Health Organization . 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