{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:54:05Z","timestamp":1782878045747,"version":"3.54.5"},"reference-count":27,"publisher":"European Respiratory Society (ERS)","issue":"6","license":[{"start":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T00:00:00Z","timestamp":1554595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.ersjournals.com\/user-licence"}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2019,3,23]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Historical data suggest 15% of laboratory animal workers develop IgE sensitisation and 10% symptoms of laboratory animal allergy (LAA), including occupational asthma. Individually ventilated cages (IVCs) are replacing conventional open cages; we sought to evaluate their impact on the development of LAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We surveyed 750 laboratory animal workers and measured airborne Mus m 1 (mouse allergen) levels in seven UK institutions. We compared the prevalence of sensitisation to mouse proteins (by specific IgE assay or skin prick test) and of work-related allergic symptoms in IVC-only and open cage units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Full-shift Mus m 1 levels were lower in IVC than open cage units (geometric mean 1.00 (95% CI 0.73\u20131.36)\n                      <jats:italic>versus<\/jats:italic>\n                      8.35 (95% CI 6.97\u20139.95) ng\u00b7m\n                      <jats:sup>\u22123<\/jats:sup>\n                      ; p&lt;0.001), but varied eight-fold across the IVC units (geometric mean range 0.33\u20134.12\u2005ng\u00b7m\n                      <jats:sup>\u22123<\/jats:sup>\n                      ). Primary analyses on data from 216 participants with \u22643\u2005years exposure to mice revealed a lower prevalence of sensitisation in those working in IVC units compared with conventional cage units (2.4% (n=2)\n                      <jats:italic>versus<\/jats:italic>\n                      9.8% (n=13); p=0.052). Sensitisation in IVC units varied from 0% to 12.5%; the use of fitted respiratory protection was less common in IVC units where prevalence of sensitisation was higher. Work-related allergy symptoms were more frequently reported by mouse-sensitised individuals (46.7%\n                      <jats:italic>versus<\/jats:italic>\n                      10.9%; p&lt;0.001) and only by those working in open cage units.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In contemporary practice, LAA is now largely preventable with the use of IVC systems and the judicious use of appropriate respiratory protection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1183\/13993003.00171-2019","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:24:05Z","timestamp":1554683045000},"page":"1900171","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Laboratory animal allergy is preventable in modern research facilities"],"prefix":"10.1183","volume":"53","author":[{"given":"Johanna R.","family":"Feary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Canizales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinir","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cullinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2019,4,7]]},"reference":[{"key":"2024102100543444000_53.6.1900171.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13e33.x"},{"key":"2024102100543444000_53.6.1900171.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-964OC"},{"key":"2024102100543444000_53.6.1900171.3","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.2.104"},{"key":"2024102100543444000_53.6.1900171.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02508.x"},{"key":"2024102100543444000_53.6.1900171.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.050"},{"key":"2024102100543444000_53.6.1900171.6","doi-asserted-by":"crossref","unstructured":"Jeal H , Jones M , Cullinan P . Epidemiology of laboratory animal allergy. In: Sigsgaard T , Heederik D , eds. Occupational Asthma (Progress in Inflammation Research). Basel, Birkhauser, 2010; pp. 33\u201335.","DOI":"10.1007\/978-3-7643-8556-9_3"},{"key":"2024102100543444000_53.6.1900171.7","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117258"},{"key":"2024102100543444000_53.6.1900171.8","doi-asserted-by":"publisher","DOI":"10.1258\/0023677011911363"},{"key":"2024102100543444000_53.6.1900171.9","unstructured":"Home Office . Annual Statistics of Scientific Procedures on Living Animals, Great Britain. 2017. www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/627284\/annual-statistics-scientific-procedures-living-animals-2016.pdf Date last accessed: February 21, 2019."},{"key":"2024102100543444000_53.6.1900171.10","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90242-3"},{"key":"2024102100543444000_53.6.1900171.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03717.x"},{"key":"2024102100543444000_53.6.1900171.12","first-page":"667","article-title":"Smoking, atopy, and laboratory animal allergy","volume":"45","author":"Venables","year":"1988","journal-title":"Br J Ind Med"},{"key":"2024102100543444000_53.6.1900171.13","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90064-0"},{"key":"2024102100543444000_53.6.1900171.14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.rmed.2015.06.007","article-title":"Long term effect and allergic sensitization in newly employed workers in laboratory animal facilities","volume":"109","author":"Palmberg","year":"2015","journal-title":"Respir Med"},{"key":"2024102100543444000_53.6.1900171.15","unstructured":"Health and Safety Executive . 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