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The dose\u2013response slope (DRS), and other continuous indices of responsiveness (CIR; the percentage decline from the post-diluent baseline FEV<jats:sub>1<\/jats:sub>after the last dose of methacholine), and per cent recovery index (PRI; the percentage increase from the maximally reduced FEV<jats:sub>1<\/jats:sub>after bronchodilator inhalation) are alternative measures. The clinical relevance of these indices in predicting acute asthma exacerbations has not been fully evaluated.<\/jats:p><jats:p>In two prospective cohorts of childhood and elderly asthmatics, baseline PC<jats:sub>20<\/jats:sub>, DRS, CIR and PRI were measured and evaluated as predictors of acute asthma exacerbations.<\/jats:p><jats:p>We found that PRI was significantly related to the presence of asthma exacerbations during the first year of follow-up in both cohorts of childhood (p=0.025) and elderly asthmatics (p=0.003). In addition, PRI showed a significant association with the total number of steroid bursts during 4.3\u2005years of follow-up in the cohort of childhood asthmatics (p=0.04).<\/jats:p><jats:p>We demonstrated that PRI, an index of reversibility following methacholine-induced bronchoconstriction, was a good clinical predictor of acute exacerbations of asthma in both childhood and elderly asthmatics.<\/jats:p>","DOI":"10.1183\/13993003.00182-2016","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T05:49:45Z","timestamp":1460612985000},"page":"104-114","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations"],"prefix":"10.1183","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-9922","authenticated-orcid":false,"given":"Heung-Woo","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Jung","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Suk","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Heon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soma","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelan G.","family":"Tantisira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"2024102023584025000_48.1.104.1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90132-9"},{"key":"2024102023584025000_48.1.104.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.6.1412"},{"key":"2024102023584025000_48.1.104.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80018-1"},{"key":"2024102023584025000_48.1.104.4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1034\/j.1399-3003.1999.14b08.x","article-title":"Tolerance to beta-agonists during acute bronchoconstriction","volume":"14","author":"Hancox","year":"1999","journal-title":"Eur Respir J"},{"key":"2024102023584025000_48.1.104.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.137844"},{"key":"2024102023584025000_48.1.104.6","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.7.529"},{"key":"2024102023584025000_48.1.104.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2012.07.004"},{"key":"2024102023584025000_48.1.104.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.03.022"},{"key":"2024102023584025000_48.1.104.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.06.012"},{"key":"2024102023584025000_48.1.104.10","first-page":"1","article-title":"Asthma prevalence, health care use, and mortality: United States, 2005\u20132009","volume":"32","author":"Akinbami","year":"2011","journal-title":"Natl Health Stat Report"},{"key":"2024102023584025000_48.1.104.11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2962"},{"key":"2024102023584025000_48.1.104.12","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2012.690481"},{"key":"2024102023584025000_48.1.104.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.022"},{"key":"2024102023584025000_48.1.104.14","doi-asserted-by":"publisher","DOI":"10.1038\/nature04176"},{"key":"2024102023584025000_48.1.104.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(98)00044-0"},{"key":"2024102023584025000_48.1.104.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010123431501"},{"key":"2024102023584025000_48.1.104.17","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12434"},{"key":"2024102023584025000_48.1.104.18","unstructured":"The Global Initiative for Asthma. 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