{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:15:32Z","timestamp":1791310532431,"version":"4.3.1"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"1","funder":[{"name":"Programme Hospitalier de Recherche Clinique","award":["NCT00980967"],"award-info":[{"award-number":["NCT00980967"]}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["HEALTH-F5-2012\/grant agreement 305457"],"award-info":[{"award-number":["HEALTH-F5-2012\/grant agreement 305457"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National research found supporting the STCS","award":["No 3347CO-108795"],"award-info":[{"award-number":["No 3347CO-108795"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2016,9,20]]},"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung transplant recipients (LTRs).<\/jats:p><jats:p>The lung function of 520 LTRs from the Cohort in Lung Transplantation (COLT) study was measured every 6\u2005months. The levels of air pollutants (nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), particulate matter with an aerodynamic cut-off diameter of x \u00b5m (PM<jats:sub>x<\/jats:sub>) and ozone (O<jats:sub>3<\/jats:sub>)) at the patients' home address were averaged in the 12\u2005months before each spirometry test. The effects of air pollutants on forced expiratory volume in 1\u2005s (FEV<jats:sub>1<\/jats:sub>) and forced vital capacity (FVC) in % predicted were estimated using mixed linear regressions. We assessed the effect modification of macrolide antibiotics in this relationship.<\/jats:p><jats:p>Increased 12-month levels of pollutants were associated with lower levels of FVC % pred (\u22122.56%, 95% CI \u22123.86\u2013\u22121.25 for 5\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>of PM<jats:sub>10<\/jats:sub>; \u22120.75%, 95% CI \u22121.38\u2013\u22120.12 for 2\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>of PM<jats:sub>2.5<\/jats:sub>and \u22122.58%, 95% CI \u22124.63\u2013\u22120.53 for 10\u2005\u00b5g\u00b7m<jats:sup>\u22123<\/jats:sup>of NO<jats:sub>2<\/jats:sub>). In patients not taking macrolides, the deleterious association between PM and FVC tended to be stronger and PM<jats:sub>10<\/jats:sub>was associated with lower FEV<jats:sub>1<\/jats:sub>.<\/jats:p><jats:p>Our study suggests a deleterious effect of chronic exposure to air pollutants on lung function levels in LTRs, which might be modified with macrolides.<\/jats:p>","DOI":"10.1183\/13993003.00206-2016","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T02:26:29Z","timestamp":1482546389000},"page":"1600206","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) 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