{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:01:33Z","timestamp":1792929693700,"version":"4.5.0"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"name":"The Lung Foundation Netherlands","award":["Grant number: 3.2.11.022"],"award-info":[{"award-number":["Grant number: 3.2.11.022"]}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2015,6,22]]},"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Several studies have investigated the effect of livestock farm emissions on the respiratory health of local residents, but results are inconsistent. This study aims to explore associations between the presence of livestock farms and respiratory health in an area of high-density livestock farming in the Netherlands. We focused especially on associations between farm exposures and respiratory symptoms within subgroups of potentially susceptible patients with a pre-existing lung disease.<\/jats:p><jats:p>In total, 14\u200a875 adults (response rate 53.4%) completed a questionnaire concerning respiratory health, smoking habits and personal characteristics. Different indicators of livestock farm exposures relative to the home address were computed using a geographic information system.<\/jats:p><jats:p>Prevalence of chronic obstructive pulmonary disease (COPD) and asthma was lower among residents living within 100\u2005m of a farm (OR 0.47, 95% CI 0.24\u20130.91 and OR 0.65, 95% CI 0.45\u20130.93, respectively). However, &gt;11 farms in 1000\u2005m compared to fewer than four farms in 1000\u2005m (fourth quartile<jats:italic>versus<\/jats:italic>first quartile) was associated with wheezing among COPD patients (OR 1.71, 95% CI 1.01\u20132.89). Using general practitioners' electronic medical records, we demonstrated that selection bias did not affect the observed associations.<\/jats:p><jats:p>Our data suggest a protective effect of livestock farm emissions on the respiratory health of residents. Nonetheless, COPD patients living near livestock farms reported more respiratory symptoms, suggesting an increased risk of exacerbations.<\/jats:p>","DOI":"10.1183\/13993003.00265-2015","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T19:23:44Z","timestamp":1438889024000},"page":"1605-1614","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":82,"title":["Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms"],"prefix":"10.1183","volume":"46","author":[{"given":"Floor","family":"Borl\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Joris","family":"Yzermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel E.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Heederik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidwien A.M.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"2024102023391394000_46.6.1605.1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.115-a298a"},{"key":"2024102023391394000_46.6.1605.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15589-X"},{"key":"2024102023391394000_46.6.1605.3","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4315-1_17"},{"key":"2024102023391394000_46.6.1605.4","first-page":"87","article-title":"Ambient endotoxin level in an area with intensive livestock production","volume":"13","author":"Schulze","year":"2006","journal-title":"Ann Agric Environ Med"},{"key":"2024102023391394000_46.6.1605.5","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-72"},{"key":"2024102023391394000_46.6.1605.6","doi-asserted-by":"publisher","DOI":"10.1080\/15459620902729184"},{"key":"2024102023391394000_46.6.1605.7","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4002"},{"key":"2024102023391394000_46.6.1605.8","unstructured":"Heederik DJJ , Ijzermans CJ . Potential Effects of Intensive Livestock Farming on Neighboring Residents\u2019 Health. Utrecht, IRAS, Utrecht University, NIVEL, RIVM, 2011."},{"key":"2024102023391394000_46.6.1605.9","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1155\/2011\/290261","article-title":"The association between endotoxin and lung function among children and adolescents living in a rural area","volume":"18","author":"Lawson","year":"2011","journal-title":"Can Respir J"},{"key":"2024102023391394000_46.6.1605.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01312.x"},{"key":"2024102023391394000_46.6.1605.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007302"},{"key":"2024102023391394000_46.6.1605.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.03.010"},{"key":"2024102023391394000_46.6.1605.13","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32835109a8"},{"key":"2024102023391394000_46.6.1605.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.6.1486"},{"key":"2024102023391394000_46.6.1605.15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2812"},{"key":"2024102023391394000_46.6.1605.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00006404"},{"key":"2024102023391394000_46.6.1605.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.12.008"},{"key":"2024102023391394000_46.6.1605.18","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182093c8b"},{"key":"2024102023391394000_46.6.1605.19","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000259966.62137.84"},{"key":"2024102023391394000_46.6.1605.20","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101485"},{"key":"2024102023391394000_46.6.1605.21","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2012.722186"},{"key":"2024102023391394000_46.6.1605.22","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20055"},{"key":"2024102023391394000_46.6.1605.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038843"},{"key":"2024102023391394000_46.6.1605.24","first-page":"1809","article-title":"Change in respiratory symptoms in young adults as they age: European community respiratory health survey 3 (ECRHS 3","volume":"42: Suppl. 57","author":"Jarvis","year":"2013","journal-title":"Eur Respir J"},{"key":"2024102023391394000_46.6.1605.25","unstructured":"Verheij RA . NIVEL Zorgregistraties Eerste Lijn: Huisarts. [Netherlands Primary Care Database: General Practitioners]. www.nivel.nl\/node\/3467 Date last accessed: January 28, 2015. Date last updated: 2014."},{"key":"2024102023391394000_46.6.1605.26","unstructured":"Lamberts H , Wood H . The International Classification of Primary Care. Oxford, Oxford University Press, 1987."},{"key":"2024102023391394000_46.6.1605.27","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9649-y"},{"key":"2024102023391394000_46.6.1605.28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1289\/ehp.8586","article-title":"Race, poverty, and potential exposure of middle-school students to air emissions from confined swine feeding operations","volume":"114","author":"Mirabelli","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2024102023391394000_46.6.1605.29","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.121-a182"},{"key":"2024102023391394000_46.6.1605.30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00801.x"},{"key":"2024102023391394000_46.6.1605.31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01325.x"},{"key":"2024102023391394000_46.6.1605.32","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.013326"},{"key":"2024102023391394000_46.6.1605.33","doi-asserted-by":"publisher","DOI":"10.1159\/000265536"},{"key":"2024102023391394000_46.6.1605.34","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2192"},{"key":"2024102023391394000_46.6.1605.35","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20077"},{"key":"2024102023391394000_46.6.1605.36","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S28286"},{"key":"2024102023391394000_46.6.1605.37","doi-asserted-by":"crossref","unstructured":"Huijskens EGW , Smit LAM , Rossen JWA , et al. Evaluation of patients with community-acquired pneumonia caused by zoonotic pathogens in an area with a high density of animal farms. Zoonoses Public Health 2015 (In press).","DOI":"10.1111\/zph.12218"},{"key":"2024102023391394000_46.6.1605.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61136-3"},{"key":"2024102023391394000_46.6.1605.39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jes.7500490"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/13993003.00265-2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:58:47Z","timestamp":1740380327000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/13993003.00265-2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,6]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,11,30]]},"published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1183\/13993003.00265-2015"],"URL":"https:\/\/doi.org\/10.1183\/13993003.00265-2015","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,6]]}}}