{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:28:27Z","timestamp":1787801307212,"version":"build-2784847793"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"3","funder":[{"DOI":"10.13039\/100004320","name":"Philips","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL095491"],"award-info":[{"award-number":["P01 HL095491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL102321"],"award-info":[{"award-number":["RO1 HL102321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2017,6,21]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Obstructive sleep apnoea (OSA) is characterised by pharyngeal obstruction occurring at different sites. Endoscopic studies reveal that epiglottic collapse renders patients at higher risk of failed oral appliance therapy or accentuated collapse on continuous positive airway pressure. Diagnosing epiglottic collapse currently requires invasive studies (imaging and endoscopy). As an alternative, we propose that epiglottic collapse can be detected from the distinct airflow patterns it produces during\u00a0sleep.<\/jats:p>\n                  <jats:p>23 OSA patients underwent natural sleep endoscopy. 1232 breaths were scored as epiglottic\/nonepiglottic collapse. Several flow characteristics were determined from the flow signal (recorded simultaneously with endoscopy) and used to build a predictive model to distinguish epiglottic from nonepiglottic collapse. Additionally, 10 OSA patients were studied to validate the pneumotachograph flow features using nasal pressure signals.<\/jats:p>\n                  <jats:p>Epiglottic collapse was characterised by a rapid fall(s) in the inspiratory flow, more variable inspiratory and expiratory flow and reduced tidal volume. The cross-validated accuracy was 84%. Predictive features obtained from pneumotachograph flow and nasal pressure were strongly correlated.<\/jats:p>\n                  <jats:p>This study demonstrates that epiglottic collapse can be identified from the airflow signal measured during a sleep study. This method may enable clinicians to use clinically collected data to characterise underlying physiology and improve treatment decisions.<\/jats:p>","DOI":"10.1183\/13993003.00345-2017","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T20:55:28Z","timestamp":1505940928000},"page":"1700345","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Predicting epiglottic collapse in patients with obstructive sleep apnoea"],"prefix":"10.1183","volume":"50","author":[{"given":"Ali","family":"Azarbarzin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Op de Beeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro R.","family":"Genta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-0335","authenticated-orcid":false,"given":"Luigi","family":"Taranto-Montemurro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M.","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Messineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier M.","family":"Vanderveken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"2024101904231805000_50.3.1700345.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"2024101904231805000_50.3.1700345.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.6.1542"},{"key":"2024101904231805000_50.3.1700345.3","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.736"},{"key":"2024101904231805000_50.3.1700345.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1633-8"},{"key":"2024101904231805000_50.3.1700345.5","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24479"},{"key":"2024101904231805000_50.3.1700345.6","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22369"},{"key":"2024101904231805000_50.3.1700345.7","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25126"},{"key":"2024101904231805000_50.3.1700345.8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23881"},{"key":"2024101904231805000_50.3.1700345.9","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815586978"},{"key":"2024101904231805000_50.3.1700345.10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1017\/S0022215100145888","article-title":"Age-related changes in the epiglottis causing failure of nasal continuous positive airway pressure therapy","volume":"113","author":"Verse","year":"1999","journal-title":"J Laryngol Otol"},{"key":"2024101904231805000_50.3.1700345.11","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.856"},{"key":"2024101904231805000_50.3.1700345.12","first-page":"2624","article-title":"Evaluation of the upper airway cross-sectional area changes in different degrees of severity of obstructive sleep apnea syndrome: cephalometric and dynamic CT study","volume":"26","author":"Yucel","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024101904231805000_50.3.1700345.13","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1007\/s00405-016-4131-1","article-title":"Dynamic upper airway collapse observed from sleep MRI: BMI-matched severe and mild OSA patients","volume":"273","author":"Huon","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2024101904231805000_50.3.1700345.14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/sleep\/26.7.857","article-title":"Prediction of inspiratory flow shapes during sleep with a mathematic model of upper airway forces","volume":"26","author":"Aittokallio","year":"2003","journal-title":"Sleep"},{"key":"2024101904231805000_50.3.1700345.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.37"},{"key":"2024101904231805000_50.3.1700345.16","doi-asserted-by":"crossref","unstructured":"Genta PR , Sands SA , Butler JP , et\u00a0al. 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