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Patients were ordered by their overall similarity concerning their multidimensional response profile, which comprises the overall response on MRC dyspnoea grade, 6MWD, cycle endurance time, Canadian Occupational Performance Measure performance and satisfaction scores, Hospital Anxiety and Depression Scale anxiety and depression, and St George's Respiratory Questionnaire total score, using a novel non-parametric regression technique.<\/jats:p><jats:p>Patients were clustered into four groups with distinct multidimensional response profiles: n=378 (18.3%; \u201cvery good responder\u201d), n=742 (35.9%; \u201cgood responder\u201d), n=731 (35.4%; \u201cmoderate responder\u201d), and n=217 (10.5%; \u201cpoor responder\u201d). Patients in the \u201cvery good responder\u201d cluster had higher symptoms of dyspnoea, number of hospitalisations &lt;12\u2005months, worse exercise performance, worse performance and satisfaction scores for problematic activities of daily life, more symptoms of anxiety and depression, worse health status, and a higher proportion of patients following an inpatient PR programme compared to the other three clusters.<\/jats:p><jats:p>A multidimensional response outcome needs to be considered to study the efficacy of pulmonary rehabilitation services in patients with COPD, as responses to regular outcomes are differential within patients with COPD.<\/jats:p>","DOI":"10.1183\/13993003.00350-2015","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:03:50Z","timestamp":1444781030000},"page":"1625-1635","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":211,"title":["Differential response to 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