{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T15:17:33Z","timestamp":1794496653309,"version":"4.9.1"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2015,9,20]]},"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis. There is lack of clarity around predictors of mortality and disease behaviour over time in these patients.<\/jats:p>\n                  <jats:p>We identified rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients evaluated at National Jewish Health (Denver, CO, USA) from 1995 to 2013 whose baseline high-resolution computed tomography (HRCT) scans showed either a nonspecific interstitial pneumonia (NSIP) or a \u201cdefinite\u201d or \u201cpossible\u201d usual interstitial pneumonia (UIP) pattern. We used univariate, multivariate and longitudinal analytical methods to identify clinical predictors of mortality and to model disease behaviour over time.<\/jats:p>\n                  <jats:p>The cohort included 137 subjects; 108 had UIP on HRCT (RA-UIP) and 29 had NSIP on HRCT (RA-NSIP). Those with RA-UIP had a shorter survival time than those with RA-NSIP (log rank p=0.02). In a model controlling for age, sex, smoking and HRCT pattern, a lower baseline % predicted forced vital capacity (FVC % pred) (HR 1.46; p&lt;0.0001) and a 10% decline in FVC % pred from baseline to any time during follow up (HR 2.57; p&lt;0.0001) were independently associated with an increased risk of death.<\/jats:p>\n                  <jats:p>Data from this study suggest that in RA-ILD, disease progression and survival differ between subgroups defined by HRCT pattern; however, when controlling for potentially influential variables, pulmonary physiology, but not HRCT pattern, independently predicts mortality.<\/jats:p>","DOI":"10.1183\/13993003.00357-2015","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T17:05:51Z","timestamp":1448384751000},"page":"588-596","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":367,"title":["Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease"],"prefix":"10.1183","volume":"47","author":[{"given":"Joshua J.","family":"Solomon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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